AChE-IN-21
Modify Date: 2025-10-05 11:27:31
AChE-IN-21 structure
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Common Name | AChE-IN-21 | ||
|---|---|---|---|---|
| CAS Number | 2413656-04-7 | Molecular Weight | 395.49 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H29NO4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AChE-IN-21AChE-IN-21 (Compound I-8) is a potent, selective and orally active AChE inhibitor with an IC50 of 2.66 nM. AChE-IN-21 displays excellent BBB permeability in vitro[1]. |
| Name | AChE-IN-21 |
|---|
| Description | AChE-IN-21 (Compound I-8) is a potent, selective and orally active AChE inhibitor with an IC50 of 2.66 nM. AChE-IN-21 displays excellent BBB permeability in vitro[1]. |
|---|---|
| Related Catalog | |
| Target |
EeAChE:2.66 nM (IC50) RatBuChE:19.10 μM (IC50) |
| In Vitro | AChE-IN-21 (Compound I-8) binds to both the catalytic active site and peripheral anionic site of AChE[1]. |
| In Vivo | AChE-IN-21 (Compound I-8) (0-25 mg/kg; i.g.; once a day for 7 consecutive days) significantly reverses scopolamine-induced memory deficit in mice[1]. Animal Model: Kunming mice at body weight of 18–22 g (male and female in half)[1] Dosage: 1.0, 5.0 and 25.0 mg/kg Administration: Intragastric administration, once a day for 7 consecutive days Result: Obviously blocked scopolamine (2 mg/kg, i.p.)-induced memory deficit. |
| References |
| Molecular Formula | C24H29NO4 |
|---|---|
| Molecular Weight | 395.49 |