Febrifugine

Modify Date: 2026-07-01 15:29:50

Febrifugine structure	Common Name	Febrifugine
	CAS Number	24159-07-7	Molecular Weight	301.340
	Density	1.4±0.1 g/cm3	Boiling Point	508.2±60.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₉N₃O₃	Melting Point	139-140°; mp 154-156°
	MSDS	N/A	Flash Point	261.1±32.9 °C

Use of Febrifugine

Febrifugine is a quinazolinone alkaloid found in the roots and leaves of Dichroa febrifuga, with antimalarial activity [1].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	Febrifugine
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Febrifugine is a quinazolinone alkaloid found in the roots and leaves of Dichroa febrifuga, with antimalarial activity [1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
References	[1]. Herman JD, et al. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Sci Transl Med. 2015 May 20;7(288):288ra77. [2]. McLaughlin NP, et al. The chemistry and biology of febrifugine and halofuginone. Bioorg Med Chem. 2014 Apr 1;22(7):1993-2004.

Description

Febrifugine is a quinazolinone alkaloid found in the roots and leaves of Dichroa febrifuga, with antimalarial activity [1].

Related Catalog

Research Areas >> Infection

Signaling Pathways >> Others >> Others

References

[1]. Herman JD, et al. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Sci Transl Med. 2015 May 20;7(288):288ra77.

[2]. McLaughlin NP, et al. The chemistry and biology of febrifugine and halofuginone. Bioorg Med Chem. 2014 Apr 1;22(7):1993-2004.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.4±0.1 g/cm3
Boiling Point	508.2±60.0 °C at 760 mmHg
Melting Point	139-140°; mp 154-156°
Molecular Formula	C₁₆H₁₉N₃O₃
Molecular Weight	301.340
Flash Point	261.1±32.9 °C
Exact Mass	301.142639
PSA	84.22000
LogP	-0.04
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.673
InChIKey	FWVHWDSCPKXMDB-CABCVRRESA-N
SMILES	O=C(CC1NCCCC1O)Cn1cnc2ccccc2c1=O
Storage condition	2-8℃

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VA3450000

CHEMICAL NAME :: 4(3H)-Quinazolinone, 3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, (2S-trans)-

CAS REGISTRY NUMBER :: 24159-07-7

LAST UPDATED :: 199707

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H19-N3-O3

MOLECULAR WEIGHT :: 301.38

WISWESSER LINE NOTATION :: T66 BVN ENJ C1V1- BT6NTJ CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JACSAT Journal of the American Chemical Society. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1879- Volume(issue)/page/year: 71,1048,1949

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,867,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 161,400,1948

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

HS Code	2933990090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 8
CAS#:1213768-41-2 (3aR,7aS)-benzy... CAS#:330798-23-7 (3S)-trans-O-ac... CAS#:32434-44-9 Isofebrifugine CAS#:244056-97-1 Benzyl 2-allyl-...
CAS#:304436-17-7 benzyl (2S,3S)-... CAS#:304436-18-8 benzyl (3aS,7aS... CAS#:304436-19-9 (3AS,7AS)-BENZY... CAS#:304436-20-2 benzyl (3aS,7aS...
DownStream 0

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Therapeutic index, ratio of IC50 for mouse/rat NG108 cells to IC50 chloroquine-resist...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4425205

Name: Antimalarial activity against Plasmodium berghei infected in po dosed mouse erythrocy...
Source: ChEMBL
Target: Plasmodium berghei
External Id: CHEMBL4425224

Name: Therapeutic index, ratio of IC50 for mouse J774 cells to IC50 chloroquine-resistant P...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4425225

Total 3, Current Page 1 of 1

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

3-{3-[(2S,3R)-3-Hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one

3-[b-Keto-g-(3-hydroxy-2-piperidyl)propyl]-4-quinazolone

(2S-trans)-3-[3-(3-Hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone

3-{3-[(2S,3R)-3-Hydroxy-2-piperidinyl]-2-oxopropyl}-4(3H)-quinazolinone

b-Dichroine

β-Dichroine

Febrifugine

febrifungine

Febrifugine (8CI)

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the CAS number of Febrifugine?

A: CAS number of Febrifugine is 24159-07-7.

Q: What English synonyms does Febrifugine have?

A: English synonyms of Febrifugine: 3-{3-[(2S,3R)-3-Hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, 3-[b-Keto-g-(3-hydroxy-2-piperidyl)propyl]-4-quinazolone, (2S-trans)-3-[3-(3-Hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone, 3-{3-[(2S,3R)-3-Hydroxy-2-piperidinyl]-2-oxopropyl}-4(3H)-quinazolinone, b-Dichroine, β-Dichroine, Febrifugine, febrifungine, Febrifugine (8CI).

Q: What is the molecular weight of Febrifugine?

A: Molecular weight of Febrifugine is 301.340.

Q: What are the uses of Febrifugine?

A: Main uses of Febrifugine: Febrifugine is a quinazolinone alkaloid found in the roots and leaves of Dichroa febrifuga, with antimalarial activity [1].

Q: What is the molecular formula of Febrifugine?

A: Molecular formula of Febrifugine is C16H19N3O3.

Q: What is the SMILES notation of Febrifugine?

A: SMILES notation of Febrifugine is O=C(CC1NCCCC1O)Cn1cnc2ccccc2c1=O.

Q: What are the storage conditions for Febrifugine?

A: Storage conditions for Febrifugine: 2-8℃.

Q: What are the upstream materials of Febrifugine?

A: Related upstream materials(CAS) of Febrifugine: 1213768-41-2;330798-23-7;32434-44-9;244056-97-1;304436-17-7;304436-18-8;304436-19-9;304436-20-2.

Q: What is the melting point of Febrifugine?

A: Melting point of Febrifugine is 139-140°; mp 154-156°.

Q: What is the InChIKey of Febrifugine?

A: InChIKey of Febrifugine is FWVHWDSCPKXMDB-CABCVRRESA-N.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

naturewill

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Febrifugine
Price: Check
Purity: 98.0%
Delivery: 10 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Febrifugine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

naturewill
China
Product Name: Febrifugine
Price: ￥Inquiry/5mg ￥Inquiry/20mg ￥Inquiry/100mg ￥Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Bella
Email: 3157321941@qq.com

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