spiclomazine

Modify Date: 2024-01-06 17:20:08

spiclomazine Structure
spiclomazine structure
Common Name spiclomazine
CAS Number 24527-27-3 Molecular Weight 446.03
Density 1.42g/cm3 Boiling Point 695.3ºC at 760mmHg
Molecular Formula C22H24ClN3OS2 Melting Point N/A
MSDS N/A Flash Point 374.3ºC

 Use of spiclomazine


Spiclomazine (Clospirazine) is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models[1].

 Names

Name 8-[3-(2-chlorophenothiazin-10-yl)propyl]-1-thia-4,8-diazaspiro[4.5]decan-3-one
Synonym More Synonyms

 spiclomazine Biological Activity

Description Spiclomazine (Clospirazine) is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models[1].
Related Catalog
Target

KRAS(G12C)

References

[1]. Guo X, et al. Spiclomazine displays a preferential anti-tumor activity in mutant KRas-driven pancreatic cancer. Oncotarget. 2018 Jan 8;9(6):6938-6951.  

 Chemical & Physical Properties

Density 1.42g/cm3
Boiling Point 695.3ºC at 760mmHg
Molecular Formula C22H24ClN3OS2
Molecular Weight 446.03
Flash Point 374.3ºC
Exact Mass 445.10500
PSA 86.18000
LogP 5.31960
Vapour Pressure 3.51E-19mmHg at 25°C
Index of Refraction 1.724

 Synonyms

Spiclomazine [INN]
Clospirazine
Spiclomazinum [INN-Latin]
Spiclomazinum
Espiclomazina
Spiclomazine