spiclomazine
Modify Date: 2024-01-06 17:20:08
spiclomazine structure
|
Common Name | spiclomazine | ||
|---|---|---|---|---|
| CAS Number | 24527-27-3 | Molecular Weight | 446.03 | |
| Density | 1.42g/cm3 | Boiling Point | 695.3ºC at 760mmHg | |
| Molecular Formula | C22H24ClN3OS2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 374.3ºC | |
Use of spiclomazineSpiclomazine (Clospirazine) is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models[1]. |
| Name | 8-[3-(2-chlorophenothiazin-10-yl)propyl]-1-thia-4,8-diazaspiro[4.5]decan-3-one |
|---|---|
| Synonym | More Synonyms |
| Description | Spiclomazine (Clospirazine) is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models[1]. |
|---|---|
| Related Catalog | |
| Target |
KRAS(G12C) |
| References |
| Density | 1.42g/cm3 |
|---|---|
| Boiling Point | 695.3ºC at 760mmHg |
| Molecular Formula | C22H24ClN3OS2 |
| Molecular Weight | 446.03 |
| Flash Point | 374.3ºC |
| Exact Mass | 445.10500 |
| PSA | 86.18000 |
| LogP | 5.31960 |
| Vapour Pressure | 3.51E-19mmHg at 25°C |
| Index of Refraction | 1.724 |
| Spiclomazine [INN] |
| Clospirazine |
| Spiclomazinum [INN-Latin] |
| Spiclomazinum |
| Espiclomazina |
| Spiclomazine |