YS-370
Modify Date: 2024-01-06 10:56:53
YS-370 structure
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Common Name | YS-370 | ||
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| CAS Number | 2470908-79-1 | Molecular Weight | 663.60 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C37H35BrN4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of YS-370YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein (P-gp). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity[1]. |
| Name | YS-370 |
|---|
| Description | YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein (P-gp). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity[1]. |
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| Molecular Formula | C37H35BrN4O3 |
|---|---|
| Molecular Weight | 663.60 |