HF50731
Modify Date: 2024-02-25 16:34:39
HF50731 structure
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Common Name | HF50731 | ||
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| CAS Number | 2484771-19-7 | Molecular Weight | 414.682 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H46N4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HF50731HF50731 (HF-50731) is a novel potent, selective CXCR4 antagonist with Ki of 19.8 nM in the CXCR4 competitive binding assay.HF50731 significantly inhibited SDF-1α-induced calcium mobilization (IC50=621 nM) and cell migration, and blocked HIV-1 infection via antagonizing CXCR4 coreceptor function (IC50=1.5 uM).The structure-activity relationship analysis demonstrated that HF50731 could primarily occupy the minor subpocket of CXCR4 and partially bind in the major subpocket by interacting with residues W94, D97, D171, and E288. |
| Name | HF50731 |
|---|
| Description | HF50731 (HF-50731) is a novel potent, selective CXCR4 antagonist with Ki of 19.8 nM in the CXCR4 competitive binding assay.HF50731 significantly inhibited SDF-1α-induced calcium mobilization (IC50=621 nM) and cell migration, and blocked HIV-1 infection via antagonizing CXCR4 coreceptor function (IC50=1.5 uM).The structure-activity relationship analysis demonstrated that HF50731 could primarily occupy the minor subpocket of CXCR4 and partially bind in the major subpocket by interacting with residues W94, D97, D171, and E288. |
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| References | 1. Xiong Fang, et al. Eur J Med Chem. 2020 Aug 15;200:112410. |
| Molecular Formula | C26H46N4 |
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| Molecular Weight | 414.682 |