AZD0865

Modify Date: 2024-01-04 15:55:55

AZD0865 structure	Common Name	AZD0865
	CAS Number	248919-64-4	Molecular Weight	366.45700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₆N₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AZD0865

AZD0865 inhibits gastric H+,K+-ATPase by K+-competitive binding. (IC50: 1.0 ± 0.2 μM)It is a acid-suppressing agents with rapid onset of action and potent acid inhibition. In vitro: AZD0865 can inhibit the final step in acid secretion. AZD0865 reduced porcine renal Na+,K+-ATPase activity by 9 ± 2%, demonstrating a high selectivity for H+,K+-ATPase.In vivo: The reference for animal administration is 0.5-1.0 mg/kg. The greater degree of acid suppression with the 75-mg dose of AZD0865 would translate to a healing rate of 89% at 4 weeks.

Name	8-[(2,6-dimethylphenyl)methylamino]-N-(2-hydroxyethyl)-2,3-dimethylimidazo[1,2-a]pyridine-6-carboxamide
Synonym	More Synonyms

Description	AZD0865 inhibits gastric H+,K+-ATPase by K+-competitive binding. (IC50: 1.0 ± 0.2 μM)It is a acid-suppressing agents with rapid onset of action and potent acid inhibition. In vitro: AZD0865 can inhibit the final step in acid secretion. AZD0865 reduced porcine renal Na+,K+-ATPase activity by 9 ± 2%, demonstrating a high selectivity for H+,K+-ATPase.In vivo: The reference for animal administration is 0.5-1.0 mg/kg. The greater degree of acid suppression with the 75-mg dose of AZD0865 would translate to a healing rate of 89% at 4 weeks.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump Research Areas >> Cancer
References	[1]. Gedda K et al. Mechanism of action of AZD0865, a K+-competitive inhibitor of gastric H+,K+-ATPase.Biochem Pharmacol. 2007 Jan 15;73(2):198-205. [2]. Kahrilas PJ et al. A randomized, comparative study of three doses of AZD0865 and esomeprazole for healing of reflux esophagitis. Clin Gastroenterol Hepatol. 2007 Dec;5(12):1385-91.

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump

Research Areas >> Cancer

References

[1]. Gedda K et al. Mechanism of action of AZD0865, a K+-competitive inhibitor of gastric H+,K+-ATPase.Biochem Pharmacol. 2007 Jan 15;73(2):198-205.

[2]. Kahrilas PJ et al. A randomized, comparative study of three doses of AZD0865 and esomeprazole for healing of reflux esophagitis. Clin Gastroenterol Hepatol. 2007 Dec;5(12):1385-91.

Molecular Formula	C₂₁H₂₆N₄O₂
Molecular Weight	366.45700
Exact Mass	366.20600
PSA	82.15000
LogP	3.54990

Linaprazan [INN:BAN]

UNII-E0OU4SC8DP

AZD0865

Linaprazan

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: AZD0865
Price: Check
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: AZD-0865
Price: $650.0/100mg $1100.0/250mg $2200.0/1g
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Linaprazan
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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AZD0865

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.