Uracil-d1

Modify Date: 2024-01-02 18:26:58

Uracil-d1 Structure
Uracil-d1 structure
Common Name Uracil-d1
CAS Number 24897-50-5 Molecular Weight 112.08700
Density 1.321g/cm3 Boiling Point 440.5ºC at 760mmHg
Molecular Formula C4H4N2O2 Melting Point N/A
MSDS N/A Flash Point 220.2ºC

 Use of Uracil-d1


Uracil-d1 is the deuterium labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].

 Names

Name Uracil-5-d
Synonym More Synonyms

 Uracil-d1 Biological Activity

Description Uracil-d1 is the deuterium labeled Uracil[1]. Uracil is a common and naturally occurring pyrimidine derivative and one of the four nucleobases in the nucleic acid of RNA[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Pałasz A, et al. In search of uracil derivatives as bioactive agents. Uracils and fused uracils: Synthesis, biological activity and applications. Eur J Med Chem. 2015 Jun 5;97:582-611.  

 Chemical & Physical Properties

Density 1.321g/cm3
Boiling Point 440.5ºC at 760mmHg
Molecular Formula C4H4N2O2
Molecular Weight 112.08700
Flash Point 220.2ºC
Exact Mass 112.02700
PSA 65.72000

 Synthetic Route

~78%

Uracil-d1 Structure

Uracil-d1

CAS#:24897-50-5

Literature: Rocek, Josef; Svata, Vladimir; Leseticky, Ladislav Collection of Czechoslovak Chemical Communications, 1985 , vol. 50, # 5 p. 1244 - 1248

~99%

Uracil-d1 Structure

Uracil-d1

CAS#:24897-50-5

Literature: Ragab, Amany E.; Grueschow, Sabine; Tromans, Daniel R.; Goss, Rebecca J. M. Journal of the American Chemical Society, 2011 , vol. 133, # 39 p. 15288 - 15291

 Precursor & DownStream

Precursor  2

DownStream  1

 Synonyms

5-deuterio-1H-pyrimidine-2,4-dione
<5-2H>uracil
C5-deuterouracil
5-Deutero-uracil
URACIL-5-D1