Beloranib

Modify Date: 2024-01-02 13:36:36

Beloranib structure	Common Name	Beloranib
	CAS Number	251111-30-5	Molecular Weight	499.63900
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₄₁NO₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Beloranib

Beloranib is an antiangiogenic fumagillin derivative. Beloranib decreases food intake, body weight, fat mass, and the size of adipocytes.

Name	[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] (E)-3-[4-[2-(dimethylamino)ethoxy]phenyl]prop-2-enoate
Synonym	More Synonyms

Description	Beloranib is an antiangiogenic fumagillin derivative. Beloranib decreases food intake, body weight, fat mass, and the size of adipocytes.
References	[1]. Elfers CT, Roth CL. Robust Reductions of Excess Weight and Hyperphagia by Beloranib in Rat Models of Genetic and Hypothalamic Obesity. Endocrinology. 2017;158(1):41-55. [2]. Kim YM, An JJ, Jin YJ, et al. Assessment of the anti-obesity effects of the TNP-470 analog, CKD-732. J Mol Endocrinol. 2007;38(4):455-465. [3]. Lee HS, Choi WK, Son HJ, et al. Absorption, distribution, metabolism, and excretion of CKD-732, a novel antiangiogenic fumagillin derivative, in rats, mice, and dogs. Arch Pharm Res. 2004;27(2):265-272. [4]. Kim EJ, Shin WH. General pharmacology of CKD-732, a new anticancer agent: effects on central nervous, cardiovascular, and respiratory system. Biol Pharm Bull. 2005;28(2):217-223.

Description

Beloranib is an antiangiogenic fumagillin derivative. Beloranib decreases food intake, body weight, fat mass, and the size of adipocytes.

References

[1]. Elfers CT, Roth CL. Robust Reductions of Excess Weight and Hyperphagia by Beloranib in Rat Models of Genetic and Hypothalamic Obesity. Endocrinology. 2017;158(1):41-55.

[2]. Kim YM, An JJ, Jin YJ, et al. Assessment of the anti-obesity effects of the TNP-470 analog, CKD-732. J Mol Endocrinol. 2007;38(4):455-465.

[3]. Lee HS, Choi WK, Son HJ, et al. Absorption, distribution, metabolism, and excretion of CKD-732, a novel antiangiogenic fumagillin derivative, in rats, mice, and dogs. Arch Pharm Res. 2004;27(2):265-272.

[4]. Kim EJ, Shin WH. General pharmacology of CKD-732, a new anticancer agent: effects on central nervous, cardiovascular, and respiratory system. Biol Pharm Bull. 2005;28(2):217-223.

Molecular Formula	C₂₉H₄₁NO₆
Molecular Weight	499.63900
Exact Mass	499.29300
PSA	73.06000
LogP	4.25980
Storage condition	-20°C

[(3R,6R,7S,8S)-7-methoxy-8-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-2-oxaspiro[2.5]octan-6-yl] (E)-3-[4-(2-dimethylaminoethyloxy)phenyl]prop-2-enoate

(3R,4S,5S,6R)-5-Methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro(2.5)octan-6-yl (2E)-3-(4-(2-(dimethylamino)ethoxy)phenyl)prop-2-enoate

Beloranib

UNII-FI471K8BU6

O-(4-(2-Dimethylaminoethoxy)-trans-cinnamoyl)fumagillol

Beloranib [INN]

ZGN-433

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Beloranib
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: ZGN-440(Beloranib)
Price: $1100.0/100mg $2000.0/250mg $3900.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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