(S)-ATPO
(S)-ATPO structure
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Common Name | (S)-ATPO | ||
|---|---|---|---|---|
| CAS Number | 252930-37-3 | Molecular Weight | 322.25 | |
| Density | N/A | Boiling Point | 569.2±60.0 °C | |
| Molecular Formula | C11H19N2O7P | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of (S)-ATPO(S)-ATPO is the (S)-enantiomer of ATPO, which is a competitive antagonist at GluR1-4 (AMPA-preferring) receptors[1]. |
| Name | 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-1,2-oxazol-4-yl]propanoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | (S)-ATPO is the (S)-enantiomer of ATPO, which is a competitive antagonist at GluR1-4 (AMPA-preferring) receptors[1]. |
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| Related Catalog | |
| In Vitro | ATPO is a competitive antagonist at GluR1-4 (AMPA-preferring) receptors[1]. |
| References |
| Boiling Point | 569.2±60.0 °C |
|---|---|
| Molecular Formula | C11H19N2O7P |
| Molecular Weight | 322.25 |
| Exact Mass | 322.09300 |
| PSA | 165.92000 |
| LogP | 1.14080 |
| Storage condition | 2-8°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
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Synthesis and pharmacology of highly selective carboxy and phosphono isoxazole amino acid AMPA receptor antagonists.
J. Med. Chem. 39 , 1682-1691, (1996) (RS)-2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA, 5) and the selective AMPA receptor antagonist (RS)-2-amino-3-[3-(carboxymethoxy)-5-methyl-4-isoxazolyl]propionic acid (AMOA, 7) ha... |
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Resolution, absolute stereochemistry, and enantiopharmacology of the GluR1-4 and GluR5 antagonist 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid.
Chirality 11 , 752-9, (1999) The phosphono amino acid, (RS)-2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl+ ++]propio nic acid (ATPO), is a structural hybrid between the NMDA antagonist (RS)-2-amino-7-phosphonoheptanoi... |
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Antagonist properties of a phosphono isoxazole amino acid at glutamate R1-4 (R,S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid receptor subtypes.
Mol. Pharmacol. 53 , 590-6, (1998) The activity of the (R, S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist, (R,S) -2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl] propionic acid (ATPO)... |
| (S)-2-amino-3-[5-tertbutyl-3-(phosphono-methoxy)-4-isoxazolyl]propionic acid |
| HMS3260C06 |
| ATPO |
| (R,S)-2-Amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid |