SEW84
SEW84 structure
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Common Name | SEW84 | ||
|---|---|---|---|---|
| CAS Number | 259089-67-3 | Molecular Weight | 422.402 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H14F4N4Os | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SEW84SEW84 (SEW04784) is a first-in-class, specific inhibitor of the Aha1-stimulated Hsp90 (ASH) ATPase activity (IC50=0.3 uM) without inhibiting basal Hsp90 ATPase;SEW84 binds to the C-terminal domain of Aha1 (Kd=1.7 uM) to weaken its asymmetric binding to Hsp90.SEW84 inhibited the GR- and AR-dependent luciferase expression with IC50 of 1.3 uM and 0.7 uM respectively.SEW84 blocks Aha1-dependent Hsp90 chaperoning activities, including the in vitro and in vivo refolding of firefly luciferase, and the transcriptional activity of the androgen receptor in cell-based models of prostate cancer.SEW84 promotes the clearance of phosphorylated tau in cellular and tissue models of neurodegenerative tauopathy. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | SEW84 |
|---|
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | SEW84 (SEW04784) is a first-in-class, specific inhibitor of the Aha1-stimulated Hsp90 (ASH) ATPase activity (IC50=0.3 uM) without inhibiting basal Hsp90 ATPase;SEW84 binds to the C-terminal domain of Aha1 (Kd=1.7 uM) to weaken its asymmetric binding to Hsp90.SEW84 inhibited the GR- and AR-dependent luciferase expression with IC50 of 1.3 uM and 0.7 uM respectively.SEW84 blocks Aha1-dependent Hsp90 chaperoning activities, including the in vitro and in vivo refolding of firefly luciferase, and the transcriptional activity of the androgen receptor in cell-based models of prostate cancer.SEW84 promotes the clearance of phosphorylated tau in cellular and tissue models of neurodegenerative tauopathy. |
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| References | 1. Jay K Singh, et al. Cell Chem Biol. 2020 Mar 19;27(3):292-305.e6. |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Molecular Formula | C19H14F4N4Os |
|---|---|
| Molecular Weight | 422.402 |
| InChIKey | QEJONNSHVNSZBJ-UHFFFAOYSA-N |
| SMILES | O=C(NNC(=S)Nc1cccc(C(F)(F)F)c1)c1cccn1-c1ccc(F)cc1 |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
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Name: Inhibitors of CDC25B-CDK2/CyclinA interaction
Source: Center for Chemical Genomics, University of Michigan
External Id: MScreen:TargetID_600
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Name: Luciferase/luciferin-expressing antifolate-resistant parasites were used to infect a ...
Source: ChEMBL
Target: HepG2-CD81
External Id: CHEMBL4483864
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Name: Luciferase/luciferin-expressing antifolate-resistant parasites were used to infect a ...
Source: ChEMBL
Target: Plasmodium berghei
External Id: CHEMBL4483863
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This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the English name of SEW84? |
| A: The English name of SEW84 is SEW84. |
| Q: What is the InChIKey of SEW84? |
| A: InChIKey of SEW84 is QEJONNSHVNSZBJ-UHFFFAOYSA-N. |
| Q: What is the molecular weight of SEW84? |
| A: Molecular weight of SEW84 is 422.402. |
| Q: What is the Chinese name of 259089-67-3? |
| A: Chinese name of 259089-67-3 is 259089-67-3. |
| Q: What is the molecular formula of SEW84? |
| A: Molecular formula of SEW84 is C19H14F4N4Os. |
| Q: What is the CAS number of SEW84? |
| A: CAS number of SEW84 is 259089-67-3. |
| Q: What is the SMILES notation of SEW84? |
| A: SMILES notation of SEW84 is O=C(NNC(=S)Nc1cccc(C(F)(F)F)c1)c1cccn1-c1ccc(F)cc1. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |