SEW84
Modify Date: 2023-02-02 23:10:21
SEW84 structure
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Common Name | SEW84 | ||
|---|---|---|---|---|
| CAS Number | 259089-67-3 | Molecular Weight | 422.402 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H14F4N4Os | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SEW84SEW84 (SEW04784) is a first-in-class, specific inhibitor of the Aha1-stimulated Hsp90 (ASH) ATPase activity (IC50=0.3 uM) without inhibiting basal Hsp90 ATPase;SEW84 binds to the C-terminal domain of Aha1 (Kd=1.7 uM) to weaken its asymmetric binding to Hsp90.SEW84 inhibited the GR- and AR-dependent luciferase expression with IC50 of 1.3 uM and 0.7 uM respectively.SEW84 blocks Aha1-dependent Hsp90 chaperoning activities, including the in vitro and in vivo refolding of firefly luciferase, and the transcriptional activity of the androgen receptor in cell-based models of prostate cancer.SEW84 promotes the clearance of phosphorylated tau in cellular and tissue models of neurodegenerative tauopathy. |
| Name | SEW84 |
|---|
| Description | SEW84 (SEW04784) is a first-in-class, specific inhibitor of the Aha1-stimulated Hsp90 (ASH) ATPase activity (IC50=0.3 uM) without inhibiting basal Hsp90 ATPase;SEW84 binds to the C-terminal domain of Aha1 (Kd=1.7 uM) to weaken its asymmetric binding to Hsp90.SEW84 inhibited the GR- and AR-dependent luciferase expression with IC50 of 1.3 uM and 0.7 uM respectively.SEW84 blocks Aha1-dependent Hsp90 chaperoning activities, including the in vitro and in vivo refolding of firefly luciferase, and the transcriptional activity of the androgen receptor in cell-based models of prostate cancer.SEW84 promotes the clearance of phosphorylated tau in cellular and tissue models of neurodegenerative tauopathy. |
|---|---|
| References | 1. Jay K Singh, et al. Cell Chem Biol. 2020 Mar 19;27(3):292-305.e6. |
| Molecular Formula | C19H14F4N4Os |
|---|---|
| Molecular Weight | 422.402 |
| InChIKey | QEJONNSHVNSZBJ-UHFFFAOYSA-N |
| SMILES | O=C(NNC(=S)Nc1cccc(C(F)(F)F)c1)c1cccn1-c1ccc(F)cc1 |