IACS-52825

Modify Date: 2025-11-25 19:40:59

IACS-52825 Structure
IACS-52825 structure
Common Name IACS-52825
CAS Number 2640376-72-1 Molecular Weight 426.29
Density N/A Boiling Point N/A
Molecular Formula C16H13F7N4O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of IACS-52825


IACS-52825 is a potent and selective DLK inhibitor with Kd of 1.3 nM, useful for the study of chemotherapy-induced peripheral neuropathy[1].

 Names

Name IACS-52825

 IACS-52825 Biological Activity

Description IACS-52825 is a potent and selective DLK inhibitor with Kd of 1.3 nM, useful for the study of chemotherapy-induced peripheral neuropathy[1].
Related Catalog
References

[1]. Kang Le, et al. Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy. J Med Chem. 2023 Jul 27;66(14):9954-9971.  

 Chemical & Physical Properties

Molecular Formula C16H13F7N4O2
Molecular Weight 426.29
InChIKey XUOJHVFYSAMHNK-GWMXKSKGSA-N
SMILES Nc1ncc(-c2cn(C34CC(F)(C3)C4)c(C(O)C(F)(F)F)n2)cc1OC(F)(F)F
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