PTD10
Modify Date: 2025-09-17 21:49:14
PTD10 structure
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Common Name | PTD10 | ||
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| CAS Number | 2642231-19-2 | Molecular Weight | 922.00 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C49H51N11O8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PTD10PTD10 is a highly potent PROTAC BTK degrader (DC50: 0.5 nM, KD: 2.28 nM). PTD10 degrades BTK in Ramos and JeKo-1 cells with DC50s of 0.5 and 0.6 nM respectively. PTD10 inhibits cell growth, and induces cell apoptosis via activation of the caspase-dependent pathway and mitochondrial pathway. PTD10 can be used for research of B-cell dysregulation[1]. |
| Name | PTD10 |
|---|
| Description | PTD10 is a highly potent PROTAC BTK degrader (DC50: 0.5 nM, KD: 2.28 nM). PTD10 degrades BTK in Ramos and JeKo-1 cells with DC50s of 0.5 and 0.6 nM respectively. PTD10 inhibits cell growth, and induces cell apoptosis via activation of the caspase-dependent pathway and mitochondrial pathway. PTD10 can be used for research of B-cell dysregulation[1]. |
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| Related Catalog | |
| References |
| Molecular Formula | C49H51N11O8 |
|---|---|
| Molecular Weight | 922.00 |
| InChIKey | DGDYTCIJBXSVPQ-XLYAUNJQSA-N |
| SMILES | CC1CN(C(=O)CNc2cccc3c2C(=O)N(C2CCC(=O)NC2=O)C3=O)CCN1c1ccc(Nc2cc(-c3ccnc(N4CCn5c(cc6c5CC(C)(C)C6)C4=O)c3CO)cn(C)c2=O)nc1 |