KM04416

Modify Date: 2024-01-02 15:14:03

KM04416 Structure
KM04416 structure
Common Name KM04416
CAS Number 26530-26-7 Molecular Weight 249.28600
Density N/A Boiling Point N/A
Molecular Formula C12H11NO3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of KM04416


KM04416, an isothiazolone derivative, is a potent glycerol-3-phosphate dehydrogenase (GPD2) inhibitor. KM04416 significantly inhibits PNT1A cell proliferation[1][2].

 Names

Name N-[(4-ethoxycarbonyl)phenyl]isothiazol-3(2H)-one
Synonym More Synonyms

 KM04416 Biological Activity

Description KM04416, an isothiazolone derivative, is a potent glycerol-3-phosphate dehydrogenase (GPD2) inhibitor. KM04416 significantly inhibits PNT1A cell proliferation[1][2].
Related Catalog
In Vitro KM04416 (20 µM; 48 小时) 对多种癌细胞系具有生长抑制作用[1]。 KM04416 (10 µM; 72小时) 显着抑制 PNT1A 细胞增殖[1]。 Cell Viability Assay[1] Cell Line: Several cancer cell lines including MDA-MB-231 and AsPC-1 as well as Huh-7, HepG2, and SK-HEP-1 cells Concentration: 20 µM Incubation Time: 48 h Result: Had a growth inhibitory effect. Cell Proliferation Assay[2] Cell Line: PNT1A cell Concentration: 10 µM Incubation Time: 72 h Result: Significantly inhibited PNT1A cell proliferation.
References

[1]. Sehyun Oh, et al. Non-bioenergetic roles of mitochondrial GPD2 promote tumor progression. Theranostics. 2023 Jan 1;13(2):438-457.  

[2]. Gurmit Singh, et al. Mitochondrial FAD-linked Glycerol-3-phosphate Dehydrogenase: A Target for Cancer Therapeutics. Pharmaceuticals (Basel). 2014 Feb 11;7(2):192-206.  

 Chemical & Physical Properties

Molecular Formula C12H11NO3S
Molecular Weight 249.28600
Exact Mass 249.04600
PSA 76.54000
LogP 2.07570

 Synonyms

KM04416
4-(3-oxo-3H-isothiazol-2-yl)-benzoic acid ethyl ester
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