KM04416
Modify Date: 2025-08-26 19:39:23
KM04416 structure
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Common Name | KM04416 | ||
|---|---|---|---|---|
| CAS Number | 26530-26-7 | Molecular Weight | 249.28600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H11NO3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KM04416KM04416, an isothiazolone derivative, is a potent glycerol-3-phosphate dehydrogenase (GPD2) inhibitor. KM04416 significantly inhibits PNT1A cell proliferation[1][2]. |
| Name | N-[(4-ethoxycarbonyl)phenyl]isothiazol-3(2H)-one |
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| Synonym | More Synonyms |
| Description | KM04416, an isothiazolone derivative, is a potent glycerol-3-phosphate dehydrogenase (GPD2) inhibitor. KM04416 significantly inhibits PNT1A cell proliferation[1][2]. |
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| Related Catalog | |
| In Vitro | KM04416 (20 µM; 48 小时) 对多种癌细胞系具有生长抑制作用[1]。 KM04416 (10 µM; 72小时) 显着抑制 PNT1A 细胞增殖[1]。 Cell Viability Assay[1] Cell Line: Several cancer cell lines including MDA-MB-231 and AsPC-1 as well as Huh-7, HepG2, and SK-HEP-1 cells Concentration: 20 µM Incubation Time: 48 h Result: Had a growth inhibitory effect. Cell Proliferation Assay[2] Cell Line: PNT1A cell Concentration: 10 µM Incubation Time: 72 h Result: Significantly inhibited PNT1A cell proliferation. |
| References |
| Molecular Formula | C12H11NO3S |
|---|---|
| Molecular Weight | 249.28600 |
| Exact Mass | 249.04600 |
| PSA | 76.54000 |
| LogP | 2.07570 |
| KM04416 |
| 4-(3-oxo-3H-isothiazol-2-yl)-benzoic acid ethyl ester |