AAL 993

Modify Date: 2024-01-10 23:04:49

AAL 993 structure	Common Name	AAL 993
	CAS Number	269390-77-4	Molecular Weight	371.356
	Density	1.3±0.1 g/cm3	Boiling Point	441.3±45.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₁₆F₃N₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	220.7±28.7 °C

Use of AAL 993

IC50s of 130 nM, 23 nM, and 18 nM for VEGFR1, VEGFR2, and VEGFR3, respectively. AAL993 shows less potently inhibits other tyrosine kinases. AAL993 possesses potent antiangiogenic and antitumor properties[1].

Name	2-[(4-Pyridinylmethyl)amino]-N-[3-(trifluoromethyl)phenyl]benzami de
Synonym	More Synonyms

Description	IC50s of 130 nM, 23 nM, and 18 nM for VEGFR1, VEGFR2, and VEGFR3, respectively. AAL993 shows less potently inhibits other tyrosine kinases. AAL993 possesses potent antiangiogenic and antitumor properties[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	VEGFR1:130 nM (IC50) VEGFR2:23 nM (IC50) VEGFR3:18 nM (IC50)
In Vitro	AAL993 suppresses HIF-1α expression through ERK inhibition without affecting Akt phosphorylation[2].
In Vivo	AAL993 (compound 5) potently inhibits VEGF-induced angiogenesis in an implant model, with an ED50 value of 7 mg/kg[1]. In B16 melanoma xenograft model, AAL993 (24-100 mg/kg; p.o.; daily; for 14days) inhibits both the growth of the primary tumor as well as the formation of spontaneous peripheral metastases[1].
References	[1]. Paul W Manley , et al. Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors. J Med Chem. 2002 Dec 19;45(26):5687-93. [2]. Hyun Seung Ban, et al. Suppression of hypoxia-induced HIF-1alpha accumulation by VEGFR inhibitors: Different profiles of AAL993 versus SU5416 and KRN633. Cancer Lett. 2010 Oct 1;296(1):17-26.

Density	1.3±0.1 g/cm3
Boiling Point	441.3±45.0 °C at 760 mmHg
Molecular Formula	C₂₀H₁₆F₃N₃O
Molecular Weight	371.356
Flash Point	220.7±28.7 °C
Exact Mass	371.124542
PSA	57.51000
LogP	4.51
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.631

2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide

2-((4-pyridyl)methyl)amino-N-(3-(trifluoromethyl)phenyl)benzamide

2-[(4-Pyridinylmethyl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide

Benzamide, 2-[(4-pyridinylmethyl)amino]-N-[3-(trifluoromethyl)phenyl]-

AAL993

DC Chemicals Limited
China
Product Name: AAL993
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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