4-Butyl-alpha-agarofuran
Modify Date: 2024-04-08 13:08:47
4-Butyl-alpha-agarofuran structure
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Common Name | 4-Butyl-alpha-agarofuran | ||
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| CAS Number | 272126-07-5 | Molecular Weight | 262.43 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H30O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 4-Butyl-alpha-agarofuran4-Butyl-alpha-agarofuran (AF 5) is an anxiolytic and antidepressant agent. 4-Butyl-alpha-agarofuran a α-agarofuran derivative that can be isolated from Gharu-wood. 4-Butyl-alpha-agarofuran can be used for the research of neurological disease research[1]. |
| Name | 4-Butyl-alpha-agarofuran |
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| Description | 4-Butyl-alpha-agarofuran (AF 5) is an anxiolytic and antidepressant agent. 4-Butyl-alpha-agarofuran a α-agarofuran derivative that can be isolated from Gharu-wood. 4-Butyl-alpha-agarofuran can be used for the research of neurological disease research[1]. |
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| Related Catalog | |
| In Vitro | 在人肝微粒体培养体系中，4-Butyl-alpha-agarofuran (2 mg) 在 100 分钟内完全代谢为羟基衍生物 I 和羰基衍生物 II[2]。 |
| In Vivo | 4-Butyl-alpha-agarofuran (0.5-10 mg/kg；腹腔注射，1 次) 在社交互动测试中显示出抗焦虑作用，显著降低纹状体、皮层和中脑的血清素 (5-HT) 水平[1]。 Animal Model: Male Wistar rats[1] Dosage: 0.5, 1.0, 2.0, 4.0, 5.0 and 10.0 mg/kg Administration: Intraperitoneal injection; 0.5, 1.0, 2.0, 4.0, 5.0 and 10.0 mg/kg; once Result: Dose-dependently prolonged the total time spent in social interaction test at a dose range of 0.5-2.0 mg/kg. Decreased the 5-HT levels in brain tissues, decreased dopamine levels of in rat striatum and midbrain and also reduced the cortical level of epinephrine at a dose of 5 mg/kg after acute administration. Decresed the extracellular dopamine level in the striatum at a dose of 10 mg/kg. |
| References |
| Molecular Formula | C18H30O |
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| Molecular Weight | 262.43 |