(R)-TTBK1-IN-1

Modify Date: 2025-09-12 10:51:27

(R)-TTBK1-IN-1 Structure
(R)-TTBK1-IN-1 structure
Common Name (R)-TTBK1-IN-1
CAS Number 2735015-59-3 Molecular Weight 337.38
Density N/A Boiling Point N/A
Molecular Formula C18H19N5O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (R)-TTBK1-IN-1


(R)-TTBK1-IN-1 is a potent, selective and brain-penetrant tau tubulin kinase 1 (TTBK1) inhibitor. (R)-TTBK1-IN-1 is an enantiomer of TTBK1-IN-1 (HY-134968). (R)-TTBK1-IN-1 can be used in the research of alzheimer’s disease and related tauopathies[1].

 Names

Name (R)-TTBK1-IN-1

 (R)-TTBK1-IN-1 Biological Activity

Description (R)-TTBK1-IN-1 is a potent, selective and brain-penetrant tau tubulin kinase 1 (TTBK1) inhibitor. (R)-TTBK1-IN-1 is an enantiomer of TTBK1-IN-1 (HY-134968). (R)-TTBK1-IN-1 can be used in the research of alzheimer’s disease and related tauopathies[1].
Related Catalog
References

[1]. Halkina T, et, al. Discovery of Potent and Brain-Penetrant Tau Tubulin Kinase 1 (TTBK1) Inhibitors that Lower Tau Phosphorylation In Vivo. J Med Chem. 2021 May 13;64(9):6358-6380.  

 Chemical & Physical Properties

Molecular Formula C18H19N5O2
Molecular Weight 337.38
InChIKey HPJVZSVEIGCFJP-GOSISDBHSA-N
SMILES CCC(C)(O)C#Cc1cc2c(ccn2-c2cc(OC)nc(N)n2)cn1
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