mHTT-IN-2
Modify Date: 2025-08-26 08:51:56
mHTT-IN-2 structure
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Common Name | mHTT-IN-2 | ||
|---|---|---|---|---|
| CAS Number | 2743336-70-9 | Molecular Weight | 395.43 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H22FN7O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of mHTT-IN-2mHTT-IN-2 (compound 27) is a potent inhibitor (EC50=0.066 μM) of mutant huntingtin (mHTT). mHTT-IN-2 reduces canonical splicing of HTT RNA exons [49-50] and is a splicing regulator of the huntingtin (HTT) gene. mHTT-IN-2 exhibits inhibitory activity in vitro and in vivo in human HD stem cells and mouse BACHD models. mHTT-IN-2 may be used in the study of branaplam-related peripheral neuropathy[1]. |
| Name | mHTT-IN-2 |
|---|
| Description | mHTT-IN-2 (compound 27) is a potent inhibitor (EC50=0.066 μM) of mutant huntingtin (mHTT). mHTT-IN-2 reduces canonical splicing of HTT RNA exons [49-50] and is a splicing regulator of the huntingtin (HTT) gene. mHTT-IN-2 exhibits inhibitory activity in vitro and in vivo in human HD stem cells and mouse BACHD models. mHTT-IN-2 may be used in the study of branaplam-related peripheral neuropathy[1]. |
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| Related Catalog | |
| Target |
EC50: 0.066 μM (mHTT protein)[1] |
| References |
| Molecular Formula | C20H22FN7O |
|---|---|
| Molecular Weight | 395.43 |