4alpha-PDD

Modify Date: 2025-08-25 16:31:52

4alpha-PDD structure	Common Name	4alpha-PDD
	CAS Number	27536-56-7	Molecular Weight	672.93100
	Density	1.14g/cm3	Boiling Point	734.2ºC at 760mmHg
	Molecular Formula	C₄₀H₆₄O₈	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	212.4ºC
	Symbol	GHS06, GHS08	Signal Word	Danger

Use of 4alpha-PDD

4α-Phorbol 12,13-didecanoate (4αPDD) is a TRPV4 agonist with antidipsogenic effects. 4α-Phorbol 12,13-didecanoate promotes Ca2+ influx[1].

Name	4alpha-phorbol 12,13-didecanoate
Synonym	More Synonyms

Description	4α-Phorbol 12,13-didecanoate (4αPDD) is a TRPV4 agonist with antidipsogenic effects. 4α-Phorbol 12,13-didecanoate promotes Ca2+ influx[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
References	[1]. Hiromi Tsushima, et al. Antidipsogenic effects of a TRPV4 agonist, 4alpha-phorbol 12,13-didecanoate, injected into the cerebroventricle. Am J Physiol Regul Integr Comp Physiol. 2006 Jun;290(6):R1736-41. [2]. Lori Birder, et al. Activation of urothelial transient receptor potential vanilloid 4 by 4alpha-phorbol 12,13-didecanoate contributes to altered bladder reflexes in the rat. J Pharmacol Exp Ther. 2007 Oct;323(1):227-35.

Description

4α-Phorbol 12,13-didecanoate (4αPDD) is a TRPV4 agonist with antidipsogenic effects. 4α-Phorbol 12,13-didecanoate promotes Ca2+ influx[1].

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

References

[1]. Hiromi Tsushima, et al. Antidipsogenic effects of a TRPV4 agonist, 4alpha-phorbol 12,13-didecanoate, injected into the cerebroventricle. Am J Physiol Regul Integr Comp Physiol. 2006 Jun;290(6):R1736-41.

[2]. Lori Birder, et al. Activation of urothelial transient receptor potential vanilloid 4 by 4alpha-phorbol 12,13-didecanoate contributes to altered bladder reflexes in the rat. J Pharmacol Exp Ther. 2007 Oct;323(1):227-35.

Density	1.14g/cm3
Boiling Point	734.2ºC at 760mmHg
Molecular Formula	C₄₀H₆₄O₈
Molecular Weight	672.93100
Flash Point	212.4ºC
Exact Mass	672.46000
PSA	130.36000
LogP	7.31330
Vapour Pressure	6.92E-25mmHg at 25°C
Index of Refraction	1.546
InChIKey	DGOSGFYDFDYMCW-OEFRVDPMSA-N
SMILES	CCCCCCCCCC(=O)OC1C(C)C2(O)C(C=C(CO)CC3(O)C(=O)C(C)=CC32)C2C(C)(C)C12OC(=O)CCCCCCCCC
Storage condition	-20°C

4alpha-PDD MSDS(Chinese)

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H300 + H310 + H330-H334-H351
Precautionary Statements	P260-P264-P280-P284-P301 + P310-P302 + P350
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T+: Very toxic;
Risk Phrases	26/27/28-40-43
Safety Phrases	36/37/39-45
RIDADR	UN 2811 6.1/PG 2
Packaging Group	III
Hazard Class	6.1(b)

Involvement of TRPV1 and TRPV4 channels in migration of rat pulmonary arterial smooth muscle cells.

Pflugers Arch. 464(3) , 261-72, (2012)

Pulmonary hypertension, the main disease of the pulmonary circulation, is characterized by an increase in pulmonary vascular resistance, involving proliferation and migration of pulmonary arterial smo...

Ca2+ entry via alpha1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium.

Am. J. Physiol. Lung Cell. Mol. Physiol. 297(4) , L650-7, (2009)

Pulmonary vascular endothelial cells express a variety of ion channels that mediate Ca(2+) influx in response to diverse environmental stimuli. However, it is not clear whether Ca(2+) influx from disc...

Salt intake augments hypotensive effects of transient receptor potential vanilloid 4: functional significance and implication.

Hypertension 53(2) , 228-35, (2009)

To test the hypothesis that activation of the transient receptor potential vanilloid 4 (TRPV4) channel conveys a hypotensive effect that is enhanced during salt load, male Wistar rats fed a normal-sod...

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