Anti-inflammatory agent 17
Modify Date: 2024-01-16 19:16:52
Anti-inflammatory agent 17 structure
|
Common Name | Anti-inflammatory agent 17 | ||
|---|---|---|---|---|
| CAS Number | 2763226-84-0 | Molecular Weight | 357.40 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H23NO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Anti-inflammatory agent 17Anti-inflammatory agent 17 is a potent and orally active anti-inflammatory agent. Anti-inflammatory agent 17 inhibits the release of IL-6 and TNF-α in vitro experiments without cytotoxicity. Anti-inflammatory agent 17 exhibits anti-inflammatory activity in vivo. Anti-inflammatory agent 17 has the potential for the research of Acute lung injury (ALI)[1]. |
| Name | Anti-inflammatory agent 17 |
|---|
| Description | Anti-inflammatory agent 17 is a potent and orally active anti-inflammatory agent. Anti-inflammatory agent 17 inhibits the release of IL-6 and TNF-α in vitro experiments without cytotoxicity. Anti-inflammatory agent 17 exhibits anti-inflammatory activity in vivo. Anti-inflammatory agent 17 has the potential for the research of Acute lung injury (ALI)[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Anti-inflammatory agent 17 (compound 5b) (10 µM; 24 h) displays no toxicity in J774a.1 cells[1]. Anti-inflammatory agent 17 (1.25, 2.5, 5, 10 µM; 2 h) inhibits the production of IL-6 (IC50=8.254 µM) and TNF-α (IC50=2.576 µM) in J774a.1 cells in a dose-dependent manner[1]. Cell Viability Assay[1] Cell Line: J774a.1 cells Concentration: 10 µM Incubation Time: 24 h Result: Displayed no toxicity in J774a.1 cells. Immunofluorescence[1] Cell Line: J774A.1 cells Concentration: 1.25, 2.5, 5, 10 µM Incubation Time: 2 h Result: Inhibited the production of IL-6 (IC50=8.254 µM) and TNF-α (IC50=2.576 µM) in J774a.1 cells in a dose-dependent manner. |
| In Vivo | Anti-inflammatory agent 17 (20 mg/kg; intragastric administration) exhibits protective effect on LPS (lipopolysaccharide)-induced ALI in mice[1]. Animal Model: C57/BL6 mice[1] Dosage: 20 mg/kg Administration: Intragastric administration Result: Exhibited protective effect on LPS-induced ALI in mice. |
| References |
| Molecular Formula | C20H23NO5 |
|---|---|
| Molecular Weight | 357.40 |