RMC-7977

Modify Date: 2024-02-22 18:25:40

RMC-7977 Structure
RMC-7977 structure
Common Name RMC-7977
CAS Number 2765082-12-8 Molecular Weight 865.09
Density N/A Boiling Point N/A
Molecular Formula C47H60N8O6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of RMC-7977


RMC-7977 is a reversible, tri-complex RAS inhibitor with broad spectrum activity for both mutant and wild-type (WT) KRAS, NRAS, and HRAS variants.RMC-7977 can lead to tumor regressions and was well tolerated in diverse RAS-addicted preclinical cancer models. RMC-7977 also can inhibit the growth of KRASG12C cancer models[1].

 Names

Name RMC-7977

 RMC-7977 Biological Activity

Description RMC-7977 is a reversible, tri-complex RAS inhibitor with broad spectrum activity for both mutant and wild-type (WT) KRAS, NRAS, and HRAS variants.RMC-7977 can lead to tumor regressions and was well tolerated in diverse RAS-addicted preclinical cancer models. RMC-7977 also can inhibit the growth of KRASG12C cancer models[1].
Related Catalog
References

[1]. Singh M, et al. Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Research Square; 2023.

 Chemical & Physical Properties

Molecular Formula C47H60N8O6S
Molecular Weight 865.09
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