N-Asn

Modify Date: 2024-01-21 10:59:00

N-Asn Structure
N-Asn structure
Common Name N-Asn
CAS Number 2776-93-4 Molecular Weight 335.31000
Density 1.53g/cm3 Boiling Point 818.5ºC at 760mmHg
Molecular Formula C12H21N3O8 Melting Point N/A
MSDS Chinese USA Flash Point 448.8ºC

 Use of N-Asn


H-Asn(glcnac-beta-D)-OH is an endogenous metabolite present in Urine that can be used for the research of NGLY1-CDDG[1][2].

 Names

Name N4-(β-N-acetyl-D-glucosaminyl)-L-asparagine
Synonym More Synonyms

 N-Asn Biological Activity

Description H-Asn(glcnac-beta-D)-OH is an endogenous metabolite present in Urine that can be used for the research of NGLY1-CDDG[1][2].
Related Catalog
In Vitro Endogenous metabolites is defined as those that are annotated by Kyoto Encyclopedia of Genes and Genomes as substrates or products of the ~1900 metabolic enzymes encoded in our genome. It is clear in the body of literature that there are documented toxic properties for many of these metabolites[1].
References

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.  

[2]. Haijes HA, et al. Aspartylglycosamine is a biomarker for NGLY1-CDDG, a congenital disorder of deglycosylation. Mol Genet Metab. 2019 Aug;127(4):368-372.  

 Chemical & Physical Properties

Density 1.53g/cm3
Boiling Point 818.5ºC at 760mmHg
Molecular Formula C12H21N3O8
Molecular Weight 335.31000
Flash Point 448.8ºC
Exact Mass 335.13300
PSA 191.44000
Vapour Pressure 4.86E-31mmHg at 25°C
Index of Refraction 1.6
Storage condition 2-8°C

 Safety Information

RIDADR NONH for all modes of transport
WGK Germany 3

 Articles27

More Articles
Synthesis of N4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-asparagine analogues. n-Butyramide, 3-chloropropionamide, 3-aminopropionamide, and isovaleramide analogues.

Carbohydr. Res. 331(4) , 439-44, (2001)

The syntheses of four analogues of N4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-asparagine are described. Activated carboxylic acids were reacted with 2-acetamido-2-deoxy-beta-D-glucopyranosylamin...

Aspartylglycosaminuria: biochemistry and molecular biology.

Biochim. Biophys. Acta 1455(2-3) , 139-54, (1999)

Aspartylglucosaminuria (AGU, McKusick 208400) is an autosomal recessive lysosomal storage disease caused by defective degradation of Asn-linked glycoproteins. AGU mutations occur in the gene (AGA) for...

Angiokeratoma corporis diffusum in a Spanish patient with aspartylglucosaminuria.

Br. J. Dermatol. 147(4) , 760-4, (2002)

Angiokeratoma corporis diffusum (ACD), initially considered to be synonymous with Fabry's disease, represents a well-known cutaneous marker of some other lysosomal enzyme disorders. Aspartylglucosamin...

 Synonyms

2-Acetamido-1-N-(β-L-aspartyl)-2-deoxy-β-D-glucopyranosylamine
N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine
2-Acetamido-2-deoxy-b-D-glucopyranosyl L-asparagine