Poly-D-lysine hydrobromide (MW 30000-70000)

Modify Date: 2024-01-02 18:49:04

Poly-D-lysine hydrobromide (MW 30000-70000) structure	Common Name	Poly-D-lysine hydrobromide (MW 30000-70000)
	CAS Number	27964-99-4	Molecular Weight	30000-70000
	Density	N/A	Boiling Point	343.7±0.0 °C at 760 mmHg
	Molecular Formula	(C₆H₁₄N₂O₂)x_.xBrH	Melting Point	N/A
	MSDS	USA	Flash Point	161.7±0.0 °C

Use of Poly-D-lysine hydrobromide (MW 30000-70000)

Poly-D-lysine hydrobromide (MW 30000-70000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide (MW 30000-70000) removes proteinase K-resistant PrP from prion-infected SN56 neuroblastoma cells without affecting PrPC[1][2].

Name	Lysine hydrobromide (1:1)
Synonym	More Synonyms

Description	Poly-D-lysine hydrobromide (MW 30000-70000) is a synthetic polymeric substrate and is one of the most widely used substrate in neural cell culture. Poly-D-lysine hydrobromide (MW 30000-70000) removes proteinase K-resistant PrP from prion-infected SN56 neuroblastoma cells without affecting PrPC[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Poly-D-lysine is immunogenic in rabbits only when injected at low doses[1]. The approximate concentration of Poly-D-lysine (PDL) needed to lower the amount of PrPres by 50% corresponds to ~0.8 μg/mL or 50 nM[2].
References	[1]. HansVermeersch, et al. Immunogenicity of poly-D-lysine, a potential polymeric drug carrier. Journal of Controlled Release. Volume 32, Issue 3, 1 December 1994, Pages 225-229. [2]. Zhou Xu, et al. Mechanistic insights into cellular alteration of prion by poly-D-lysine: the role of H2H3 domain. FASEB J. 2011 Oct;25(10):3426-35.

Boiling Point	343.7±0.0 °C at 760 mmHg
Molecular Formula	(C₆H₁₄N₂O₂)x_.xBrH
Molecular Weight	30000-70000
Flash Point	161.7±0.0 °C
Exact Mass	226.031677
Appearance of Characters	lyophilized powder
Vapour Pressure	0.0±0.0 mmHg at 25°C
Storage condition	−20°C
Water Solubility	Soluble in water.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

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MFCD00131934

Lysine hydrobromide (1:1)

Lysine, hydrobromide (1:1)

Poly-D-lysine hydrobromide (MW 30000-70000)

Use of Poly-D-lysine hydrobromide (MW 30000-70000)

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