Piperidine,2-[(2S,4S)-2-ethyl-2-phenyl-1,3-dioxolan-4-yl]-, (2S)-

Modify Date: 2025-08-27 12:51:49

Piperidine,2-[(2S,4S)-2-ethyl-2-phenyl-1,3-dioxolan-4-yl]-, (2S)- structure	Common Name	Piperidine,2-[(2S,4S)-2-ethyl-2-phenyl-1,3-dioxolan-4-yl]-, (2S)-
	CAS Number	28189-85-7	Molecular Weight	261.35900
	Density	1.057g/cm3	Boiling Point	373ºC at 760mmHg
	Molecular Formula	C₁₆H₂₃NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	157.4ºC

Use of Piperidine,2-[(2S,4S)-2-ethyl-2-phenyl-1,3-dioxolan-4-yl]-, (2S)-

Etoxadrol is a potent N-methyl-D-aspartic acid (NMDA) antagonist with high affinity. Etoxadrol can be used for anaesthetic research[1].

Name	2-(2-ethyl-2-phenyl-1,3-dioxolan-4-yl)piperidine
Synonym	More Synonyms

Description	Etoxadrol is a potent N-methyl-D-aspartic acid (NMDA) antagonist with high affinity. Etoxadrol can be used for anaesthetic research[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	NMDA[1]
In Vivo	Etoxadrol (100.0 mg/kg; i.h.; 30 min) produces marked stimulation and ataxia in mice[2]. Animal Model: Carworth-Farm (Upjohn) male mice weighing 18 to 20 gm[2] Dosage: 100.0 mg/kg Administration: Subcutaneous injection, 30 min Result: Produced marked stimulation and ataxia.
References	[1]. A Thurkauf, et al. Synthesis, absolute configuration, and molecular modeling study of etoxadrol, a potent phencyclidine-like agonist. J Med Chem. 1988 Dec;31(12):2257-63. [2]. A H Tang, et al. Analgetic activities of etoxadrol in the rhesus monkey and in mice. Anesth Analg. 1973 Jul-Aug;52(4):577-83.

Density	1.057g/cm3
Boiling Point	373ºC at 760mmHg
Molecular Formula	C₁₆H₂₃NO₂
Molecular Weight	261.35900
Flash Point	157.4ºC
Exact Mass	261.17300
PSA	30.49000
LogP	3.13570
Index of Refraction	1.52
InChIKey	INOYCBNLWYEPSB-UHFFFAOYSA-N
SMILES	CCC1(c2ccccc2)OCC(C2CCCCN2)O1

HS Code	2933399090

1,1-dimethoxypr...

CAS#:25310-92-3

α-(S,S)-1-(2-pi...

CAS#:30162-99-3

N/A

CAS#:117019-61-1

Piperidine,2-[(...

CAS#:28189-85-7

Literature: Thurkauf; Mattson; Richardson; Mirsadeghi; Ornstein; Harrison Jr.; Rice; Jacobson; Monn Journal of Medicinal Chemistry, 1992 , vol. 35, # 8 p. 1323 - 1329

Precursor 2
CAS#:25310-92-3 1,1-dimethoxypr... CAS#:30162-99-3 α-(S,S)-1-(2-pi...
DownStream 0

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

CL-1848C

Piperidine,3-dioxolan-4-yl)

ETOXADROL

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