FTX-6746

Modify Date: 2026-08-06 15:07:26

FTX-6746 structure	Common Name	FTX-6746
	CAS Number	2829349-96-2	Molecular Weight	316.69
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₇ClF₂N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of FTX-6746

FTX-6746 is an orally active PPARG inhibitor. FTX-6746 shows potent tumor inhibition in mouse xenograft models[1].

Name	FTX-6746

Description	FTX-6746 is an orally active PPARG inhibitor. FTX-6746 shows potent tumor inhibition in mouse xenograft models[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR
Target	PPARγ
In Vivo	FTX-6746 (3-60 mg/kg；口服；每天 2 次，共 21 天) 在小鼠的 UMUC9 或 HT1197 异种移植模型中有显着的肿瘤抑制作用[1]。 Animal Model: UMUC9 or HT1197 xenograft model in NCG or Balb/C nude mice[1] Dosage: 3 mg/kg, 10 mg/kg, 30 mg/kg, 60 mg/kg Administration: PO; twice daily for 21 days Result: Resulted >100% tumor growth inhibition at day 21 in HT1197 xenograft model. Resulted up to 80% target gene suppression in tumor tissue at day 2.
References	[1]. Mertz J, et al. Novel inhibitors of the luminal lineage transcription factor peroxisome proliferator-activated receptor gamma (PPARG) durably eradicate tumors in urothelial cancer (UC) animal models[J]. European Journal of Cancer, 2022, 174: S33-S34.

Molecular Formula	C₁₆H₇ClF₂N₂O
Molecular Weight	316.69
InChIKey	PCCCYEBARWZCEY-UHFFFAOYSA-N
SMILES	N#Cc1ccc(Cl)c(-c2cc(=O)c3c(F)cc(F)cc3[nH]2)c1

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: FTX-6476
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
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