Firazorexton hydrate

Modify Date: 2024-01-13 06:06:04

Firazorexton hydrate Structure
Firazorexton hydrate structure
 Common Name Firazorexton hydrate
CAS Number 2861934-86-1 Molecular Weight 497.53
Density N/A Boiling Point N/A
Molecular Formula C22H25F3N2O4S.3/2H2O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Firazorexton hydrate


Firazorexton hydrate (TAK-994) is a potent, brain-penetrant, and orally active orexin type 2 receptor (OX2R) agonist (EC50: 19 nM). Firazorexton hydrate inhibits fragmentation of wakefulness and cataplexy-like episodes in mouse models of narcolepsy[1].

 Names

Name Firazorexton hydrate

 Firazorexton hydrate Biological Activity

Description Firazorexton hydrate (TAK-994) is a potent, brain-penetrant, and orally active orexin type 2 receptor (OX2R) agonist (EC50: 19 nM). Firazorexton hydrate inhibits fragmentation of wakefulness and cataplexy-like episodes in mouse models of narcolepsy[1].
Related Catalog
Target

EC50: 19 nM (OX2R)[1]

References

[1]. Ishikawa T, et al. TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcolepsy. J Pharmacol Exp Ther. 2023 Jun;385(3):193-204.  

 Chemical & Physical Properties

Molecular Formula C22H25F3N2O4S.3/2H2O
Molecular Weight 497.53
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