Antiproliferative agent-34
Modify Date: 2025-08-26 09:29:44
Antiproliferative agent-34 structure
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Common Name | Antiproliferative agent-34 | ||
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| CAS Number | 2910858-34-1 | Molecular Weight | 529.55 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H27N7O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Antiproliferative agent-34Antiproliferative agent-34 (Compound A14) is a multi-target kinase inhibitor, with an IC50 of 177 nM and 1567 nM for EGFR L858R/T790M and EGFR WT. Antiproliferative agent-34 also inhibits JAK2, ROS1, FLT3, FLT4, PDGFRα with IC50 of 30.93, 106.90, 108.00, 226.60, 42.53 nM. Antiproliferative agent-34 inhibits H1975 and HCC827 cells proliferation with IC50 values below 40 nM under normoxic condition, and the anti-proliferation potency achieves 4–6-fold improvement (IC50 values < 10 nM) under hypoxic condition[1]. |
| Name | Antiproliferative agent-34 |
|---|
| Description | Antiproliferative agent-34 (Compound A14) is a multi-target kinase inhibitor, with an IC50 of 177 nM and 1567 nM for EGFR L858R/T790M and EGFR WT. Antiproliferative agent-34 also inhibits JAK2, ROS1, FLT3, FLT4, PDGFRα with IC50 of 30.93, 106.90, 108.00, 226.60, 42.53 nM. Antiproliferative agent-34 inhibits H1975 and HCC827 cells proliferation with IC50 values below 40 nM under normoxic condition, and the anti-proliferation potency achieves 4–6-fold improvement (IC50 values < 10 nM) under hypoxic condition[1]. |
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| Related Catalog | |
| Target |
177, 30.93, 106.90, 108.00, 226.60, 42.53 nM for EGFR L858R/T790M, JAK2, ROS1, FLT3, FLT4, PDGFRα respectively[1] |
| References |
| Molecular Formula | C27H27N7O5 |
|---|---|
| Molecular Weight | 529.55 |
| InChIKey | KRHJQHMWPVTYCU-UHFFFAOYSA-N |
| SMILES | COc1ccc(Nc2nccc(-c3cn(C)c4ccccc34)n2)cc1OCCOCCn1ccnc1[N+](=O)[O-] |