AD4

Modify Date: 2024-03-07 20:16:17

AD4 structure	Common Name	AD4
	CAS Number	2918262-09-4	Molecular Weight	1035.23
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₅H₇₈N₄O₁₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AD4

AD4 is an artemisinin derivative that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4;11 cells (IC50: 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged survival of RS4;11-transplanted NOD/SCID mice, with in vivo efficacy[1].

Name	AD4

Description	AD4 is an artemisinin derivative that is a proteolytic targeting chimera (PROTAC) targeting PCLAF. AD4 can effectively degrade PCLAF in RS4;11 cells (IC50: 0.6 nM), thereby activating the p21/Rb axis and exerting anti-tumor activity. AD4 also prolonged survival of RS4;11-transplanted NOD/SCID mice, with in vivo efficacy[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Signaling Pathways >> PROTAC >> PROTAC
Target	IC50: 0.6 nM (PCLAF/KIAA0101)[1]
References	[1]. Li Y, et al. Facilitated Drug Repurposing with Artemisinin-Derived PROTACs: Unveiling PCLAF as a Therapeutic Target. J Med Chem. 2023 Aug 24;66(16):11335-11350..

Molecular Formula	C₅₅H₇₈N₄O₁₅
Molecular Weight	1035.23

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AD4

Use of AD4

Names

AD4 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.