CH7233163

Modify Date: 2025-08-20 21:35:05

CH7233163 structure	Common Name	CH7233163
	CAS Number	2923365-71-1	Molecular Weight	669.72
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₁H₃₄F₃N₉O₃S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of CH7233163

CH7233163 is a noncovalent ATP-competitive inhibitor for EGFR-Del19/T790M/C797S. CH7233163 can overcome Osimertinib (HY-15772)-Resistant EGFR-Del19/T790M/C797S mutation. CH7233163 blocks the EGFR phosphorylation in the Del19/T790M/C797S_NIH3T3 cells. CH7233163 has antitumor activities[1].

Name	CH7233163

Description	CH7233163 is a noncovalent ATP-competitive inhibitor for EGFR-Del19/T790M/C797S. CH7233163 can overcome Osimertinib (HY-15772)-Resistant EGFR-Del19/T790M/C797S mutation. CH7233163 blocks the EGFR phosphorylation in the Del19/T790M/C797S_NIH3T3 cells. CH7233163 has antitumor activities[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
References	[1]. Kashima K, et al. CH7233163 Overcomes Osimertinib-Resistant EGFR-Del19/T790M/C797S Mutation. Mol Cancer Ther. 2020 Nov;19(11):2288-2297.

Molecular Formula	C₃₁H₃₄F₃N₉O₃S
Molecular Weight	669.72
InChIKey	KMBMYNDPNVGEFI-UHFFFAOYSA-N
SMILES	CC(C)n1c2cc(Nc3ccnc(-c4cnn(S(=O)(=O)C5CC5)c4)n3)ncc2c2c(OCC(F)(F)F)cc(N3CCN(C)CC3)cc21

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CH7233163

Use of CH7233163

Names

CH7233163 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.