SB-1436

Modify Date: 2024-01-30 13:28:21

SB-1436 Structure
SB-1436 structure
 Common Name SB-1436
CAS Number 2925298-08-2 Molecular Weight 405.89
Density N/A Boiling Point N/A
Molecular Formula C25H21ClFNO Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SB-1436


SB-1436 is an Cholinesterase (ChE) inhibitor, inhibits acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and recombinant human acetylcholinesterase (rHuAChE) with IC50s of 0.176, 0.37 and 0.08 μM, respectively. SB-1436 inhibits AChE and BChE in a non-competitive manner with Kis of 0.046 and 0.115 μM, respectively. SB-1436 significantly stops the self-aggregation of Aβ, and can be used for neurological disease research[1].

 Names

Name SB-1436

 SB-1436 Biological Activity

Description SB-1436 is an Cholinesterase (ChE) inhibitor, inhibits acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and recombinant human acetylcholinesterase (rHuAChE) with IC50s of 0.176, 0.37 and 0.08 μM, respectively. SB-1436 inhibits AChE and BChE in a non-competitive manner with Kis of 0.046 and 0.115 μM, respectively. SB-1436 significantly stops the self-aggregation of Aβ, and can be used for neurological disease research[1].
Related Catalog
Target

EeAChE:0.176 μM (IC50)

eqBCHE:0.37 μM (IC50)

EeAChE:0.046 μM (Ki)

eqBCHE:0.115 μM (Ki)

References

[1]. Abdullaha M, et.al. Methoxy-naphthyl-Linked N-Benzyl Pyridinium Styryls as Dual Cholinesterase Inhibitors: Design, Synthesis, Biological Evaluation, and Structure-Activity Relationship. ACS Omega. 2023 May 9;8(20):17591-17608.  

 Chemical & Physical Properties

Molecular Formula C25H21ClFNO
Molecular Weight 405.89
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Chemsrc provides SB-1436(CAS#:2925298-08-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of SB-1436 are included as well.>> amp version: SB-1436

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