(4R)-2-Undecyl-1,3-thiazolidine-4-carboxylic acid

Modify Date: 2024-01-06 14:46:09

(4R)-2-Undecyl-1,3-thiazolidine-4-carboxylic acid Structure
(4R)-2-Undecyl-1,3-thiazolidine-4-carboxylic acid structure
Common Name (4R)-2-Undecyl-1,3-thiazolidine-4-carboxylic acid
CAS Number 298186-80-8 Molecular Weight 287.461
Density 1.0±0.1 g/cm3 Boiling Point 439.2±40.0 °C at 760 mmHg
Molecular Formula C15H29NO2S Melting Point N/A
MSDS Chinese USA Flash Point 219.4±27.3 °C

 Use of (4R)-2-Undecyl-1,3-thiazolidine-4-carboxylic acid


CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist. CAY10444 inhibits by 37% S1P-induced increases in Ca2+ in HeLa cells expressing S1P3 receptors[1].

 Names

Name (4R)-2-Undecyl-4-thiazolidinecarboxylic acid
Synonym More Synonyms

  Biological Activity

Description CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist. CAY10444 inhibits by 37% S1P-induced increases in Ca2+ in HeLa cells expressing S1P3 receptors[1].
Related Catalog
Target

S1PR3

In Vitro BML-241 inhibits increases in intracellular Ca2+ concentration via P2 receptor or α1A-adrenoceptor stimulation and α1A-adrenoceptor-mediated contraction of rat mesenteric artery, while it does not affect S1P3-mediated decrease of Forskolin-induced cyclic AMP accumulation[1].
References

[1]. Salvatore Salomone, et al. Selectivity and specificity of sphingosine-1-phosphate receptor ligands: caveats and critical thinking in characterizing receptor-mediated effects. Front Pharmacol. 2011 Feb 22;2:9.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 439.2±40.0 °C at 760 mmHg
Molecular Formula C15H29NO2S
Molecular Weight 287.461
Flash Point 219.4±27.3 °C
Exact Mass 287.191895
PSA 74.63000
LogP 5.42
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.495
Storage condition -20°C

 Safety Information

RIDADR NONH for all modes of transport
HS Code 2934999090

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2-Undecylthiazolidine-4(R)-carboxylic acid
4-Thiazolidinecarboxylic acid, 2-undecyl-, (4R)-
(4R)-2-Undecyl-1,3-thiazolidine-4-carboxylic acid
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