U-18666A

Modify Date: 2024-01-06 07:52:45

U-18666A Structure
U-18666A structure
Common Name U-18666A
CAS Number 3039-71-2 Molecular Weight 424.060
Density N/A Boiling Point N/A
Molecular Formula C25H42ClNO2 Melting Point N/A
MSDS USA Flash Point N/A

 Use of U-18666A


U18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor.

 Names

Name (3S,8R,9S,10R,13S,14S)-3-[2-(diethylamino)ethoxy]-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one,hydrochloride
Synonym More Synonyms

 U-18666A Biological Activity

Description U18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor.
Related Catalog
Target

Cholesterol[1][2].

In Vitro U18666A, the antiviral effect is found to result from two events: retarded viral trafficking in the cholesterol-loaded late endosomes/lysosomes and suppresse de novo sterol biosynthesis in treated infected cells. It is also observed an additive antiviral effect of U18666A with C75, a fatty acid synthase inhibitor, suggesting dengue virus relies on both the host cholesterol and fatty acid biosynthesis for successful replication[1][2].
References

[1]. Poh MK, et al. U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication. Antiviral Res. 2012 Jan;93(1):191-8.

[2]. Cenedella RJ, et al. Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes. Lipids. 2009 Jun;44(6):477-87.

 Chemical & Physical Properties

Molecular Formula C25H42ClNO2
Molecular Weight 424.060
Exact Mass 423.290405
PSA 29.54000
LogP 6.04730
Storage condition 2-8℃

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Articles28

More Articles
Itraconazole suppresses the growth of glioblastoma through induction of autophagy: involvement of abnormal cholesterol trafficking.

Autophagy 10(7) , 1241-55, (2014)

Glioblastoma is one of the most aggressive human cancers with poor prognosis, and therefore a critical need exists for novel therapeutic strategies for management of glioblastoma patients. Itraconazol...

Role of cathepsin D in U18666A-induced neuronal cell death: potential implication in Niemann-Pick type C disease pathogenesis.

J. Biol. Chem. 288(5) , 3136-52, (2013)

Cathepsin D is an aspartyl protease that plays a crucial role in normal cellular functions and in a variety of neurodegenerative disorders, including Niemann-Pick type C (NPC) disease, which is charac...

Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells.

PLoS ONE 7 , e30051, (2012)

A variety of intercalating amphipaths increase the chemical activity of plasma membrane cholesterol. To test whether intracellular cholesterol can be similarly activated, we examined NPC1 and NPC2 fib...

 Synonyms

Androst-5-en-17-one, 3-[2- (diethylamino)ethoxy]-, hydrochloride, (3β)-
(3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride (1:1)
Androst-5-en-17-one, 3β-(2-(diethylamino)ethoxy)-, hydrochloride (8CI)
Androst-5-en-17-one, 3β-[2- (diethylamino)ethoxy]-, hydrochloride
Androst-5-en-17-one, 3-(2-(diethylamino)ethoxy)-, hydrochloride, (3β)-
Androst-5-en-17-one, 3-[2-(diethylamino)ethoxy]-, (3β)-, hydrochloride (1:1)
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