U-18666A
U-18666A structure
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Common Name | U-18666A | ||
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| CAS Number | 3039-71-2 | Molecular Weight | 424.060 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H42ClNO2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of U-18666AU18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor. |
| Name | (3S,8R,9S,10R,13S,14S)-3-[2-(diethylamino)ethoxy]-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one,hydrochloride |
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| Synonym | More Synonyms |
| Description | U18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor. |
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| Related Catalog | |
| Target |
Cholesterol[1][2]. |
| In Vitro | U18666A, the antiviral effect is found to result from two events: retarded viral trafficking in the cholesterol-loaded late endosomes/lysosomes and suppresse de novo sterol biosynthesis in treated infected cells. It is also observed an additive antiviral effect of U18666A with C75, a fatty acid synthase inhibitor, suggesting dengue virus relies on both the host cholesterol and fatty acid biosynthesis for successful replication[1][2]. |
| References |
| Molecular Formula | C25H42ClNO2 |
|---|---|
| Molecular Weight | 424.060 |
| Exact Mass | 423.290405 |
| PSA | 29.54000 |
| LogP | 6.04730 |
| Storage condition | 2-8℃ |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Itraconazole suppresses the growth of glioblastoma through induction of autophagy: involvement of abnormal cholesterol trafficking.
Autophagy 10(7) , 1241-55, (2014) Glioblastoma is one of the most aggressive human cancers with poor prognosis, and therefore a critical need exists for novel therapeutic strategies for management of glioblastoma patients. Itraconazol... |
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Role of cathepsin D in U18666A-induced neuronal cell death: potential implication in Niemann-Pick type C disease pathogenesis.
J. Biol. Chem. 288(5) , 3136-52, (2013) Cathepsin D is an aspartyl protease that plays a crucial role in normal cellular functions and in a variety of neurodegenerative disorders, including Niemann-Pick type C (NPC) disease, which is charac... |
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Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells.
PLoS ONE 7 , e30051, (2012) A variety of intercalating amphipaths increase the chemical activity of plasma membrane cholesterol. To test whether intracellular cholesterol can be similarly activated, we examined NPC1 and NPC2 fib... |
| Androst-5-en-17-one, 3-[2- (diethylamino)ethoxy]-, hydrochloride, (3β)- |
| (3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride (1:1) |
| Androst-5-en-17-one, 3β-(2-(diethylamino)ethoxy)-, hydrochloride (8CI) |
| Androst-5-en-17-one, 3β-[2- (diethylamino)ethoxy]-, hydrochloride |
| Androst-5-en-17-one, 3-(2-(diethylamino)ethoxy)-, hydrochloride, (3β)- |
| Androst-5-en-17-one, 3-[2-(diethylamino)ethoxy]-, (3β)-, hydrochloride (1:1) |