CMPD167
Modify Date: 2022-01-31 12:30:28
CMPD167 structure
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Common Name | CMPD167 | ||
|---|---|---|---|---|
| CAS Number | 313994-79-5 | Molecular Weight | 574.772 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 694.4±55.0 °C at 760 mmHg | |
| Molecular Formula | C35H47FN4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 373.8±31.5 °C | |
Use of CMPD167CMPD167 (MRK-1) is an orally acitve small molecule that binds to CCR5 to inhibit gp120 association, inhibits different stages of the virus-cell attachment and entry process (CCR5-using virus SHIV-162P3, IC50<1 nM). |
| Name | MRK-1 |
|---|---|
| Synonym | More Synonyms |
| Description | CMPD167 (MRK-1) is an orally acitve small molecule that binds to CCR5 to inhibit gp120 association, inhibits different stages of the virus-cell attachment and entry process (CCR5-using virus SHIV-162P3, IC50<1 nM). |
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| References | References 1. Veazey RS, et al. Nature. 2005 Nov 3;438(7064):99-102. 2. Veazey RS, et al. Nat Med. 2005 Dec;11(12):1293-4. 3. Ketas TJ, et al. Virology. 2007 Aug 1;364(2):431-40. 4. Malcolm RK, et al. Antimicrob Agents Chemother. 2012 May;56(5):2251-8. View Related Products by Target Chemokine Receptor (CCR and CXCR) |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 694.4±55.0 °C at 760 mmHg |
| Molecular Formula | C35H47FN4O2 |
| Molecular Weight | 574.772 |
| Flash Point | 373.8±31.5 °C |
| Exact Mass | 574.368286 |
| LogP | 6.27 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.607 |
| N-[(1R,3S,4S)-3-{[4-(3-Benzyl-1-ethyl-1H-pyrazol-5-yl)-1-piperidinyl]methyl}-4-(3-fluorophenyl)cyclopentyl]-N-methyl-D-valine |
| D-Valine, N-[(1R,3S,4S)-3-[[4-[1-ethyl-3-(phenylmethyl)-1H-pyrazol-5-yl]-1-piperidinyl]methyl]-4-(3-fluorophenyl)cyclopentyl]-N-methyl- |
| MRK-1 |