Moricizine
Modify Date: 2024-01-06 09:01:14
Moricizine structure
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Common Name | Moricizine | ||
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| CAS Number | 31883-05-3 | Molecular Weight | 427.51700 | |
| Density | 1.315g/cm3 | Boiling Point | 625ºC at 760 mmHg | |
| Molecular Formula | C22H25N3O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 331.8ºC | |
Use of MoricizineMoricizine is an antiarrhythmia agent used primarily for ventricular rhythm disturbances.Target: Sodium ChannelMoricizine is an antiarrhythmia agent used primarily for ventricular rhythm disturbances. Moricizine works by inhibiting the rapid inward sodium current across myocardial cell membranes. Moricizine induced the tonic block of INa with the apparent dissociation constant (Kd,app) of 6.3 microM at -100 mV and 99.3 microM at -140 mV. Moricizine at 30 microM shifted the h infinity curve to the hyperpolarizing direction by 8.6 +/- 2.4 mV. Moricizine also produced the phasic block of INa, which was enhanced with the increase in the duration of train pulses, and was more prominent with a holding potential (HP) of -100 mV than with an HP of -140 mV. Moricizine would exert an antiarrhythmic action on atrial myocytes, as well as on ventricular myocytes, by blocking Na+ channels with a high affinity to the inactivated state and a slow dissociation kinetics [1]. |
| Name | moricizine |
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| Synonym | More Synonyms |
| Description | Moricizine is an antiarrhythmia agent used primarily for ventricular rhythm disturbances.Target: Sodium ChannelMoricizine is an antiarrhythmia agent used primarily for ventricular rhythm disturbances. Moricizine works by inhibiting the rapid inward sodium current across myocardial cell membranes. Moricizine induced the tonic block of INa with the apparent dissociation constant (Kd,app) of 6.3 microM at -100 mV and 99.3 microM at -140 mV. Moricizine at 30 microM shifted the h infinity curve to the hyperpolarizing direction by 8.6 +/- 2.4 mV. Moricizine also produced the phasic block of INa, which was enhanced with the increase in the duration of train pulses, and was more prominent with a holding potential (HP) of -100 mV than with an HP of -140 mV. Moricizine would exert an antiarrhythmic action on atrial myocytes, as well as on ventricular myocytes, by blocking Na+ channels with a high affinity to the inactivated state and a slow dissociation kinetics [1]. |
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| Related Catalog | |
| References |
| Density | 1.315g/cm3 |
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| Boiling Point | 625ºC at 760 mmHg |
| Molecular Formula | C22H25N3O4S |
| Molecular Weight | 427.51700 |
| Flash Point | 331.8ºC |
| Exact Mass | 427.15700 |
| PSA | 96.41000 |
| LogP | 4.18250 |
| Index of Refraction | 1.639 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| HS Code | 2934999090 |
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| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Moracizin |
| Moracizina [INN-Spanish] |
| Moracizinum |
| ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate |
| Moracizine |
| Moracizina |
| Ethmozin |
| [10-(3-morpholin-4-yl-propionyl)-10H-phenothiazin-2-yl]-carbamic acid ethyl ester |
| Ethmozine |
| Etmozin |
| MORICIZINE |
| Moracizinum [INN-Latin] |
| EINECS 250-854-5 |