3-carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid

Modify Date: 2024-01-01 21:58:14

3-carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid Structure
3-carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid structure
Common Name 3-carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid
CAS Number 320-77-4 Molecular Weight 192.12400
Density 1.751g/cm3 Boiling Point 329.6ºC at 760 mmHg
Molecular Formula C6H8O7 Melting Point N/A
MSDS N/A Flash Point 167.4ºC

 Use of 3-carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid


Isocitric acid is an endogenous metabolite present in Saliva and Cellular_Cytoplasm that can be used for the research of Alzheimer's Disease, Lewy Body Dementia and Anoxia[1][2][3].

 Names

Name isocitric acid
Synonym More Synonyms

  Biological Activity

Description Isocitric acid is an endogenous metabolite present in Saliva and Cellular_Cytoplasm that can be used for the research of Alzheimer's Disease, Lewy Body Dementia and Anoxia[1][2][3].
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Endogenous metabolites is defined as those that are annotated by Kyoto Encyclopedia of Genes and Genomes as substrates or products of the ~1900 metabolic enzymes encoded in our genome. It is clear in the body of literature that there are documented toxic properties for many of these metabolites[1].
References

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.  

[2]. Tsuruoka M, et al. Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72.  

[3]. Zupke C, et al. Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Appl Microbiol Biotechnol. 1995 Dec;44(1-2):27-36.  

 Chemical & Physical Properties

Density 1.751g/cm3
Boiling Point 329.6ºC at 760 mmHg
Molecular Formula C6H8O7
Molecular Weight 192.12400
Flash Point 167.4ºC
Exact Mass 192.02700
PSA 132.13000
Index of Refraction 1.569

 Synthetic Route

~98%

3-carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid Structure

3-carboxy-2,3-d...

CAS#:320-77-4

Literature: Sugimura, Kenji; Kuwabata, Susumu; Yoneyama, Hiroshi Journal of the American Chemical Society, 1989 , vol. 111, # 6 p. 2361 - 2362

~%

3-carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid Structure

3-carboxy-2,3-d...

CAS#:320-77-4

Literature: Terasawa, Masato; Takahashi, Joji Agricultural and Biological Chemistry, 1981 , vol. 45, # 11 p. 2433 - 2442

~%

3-carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid Structure

3-carboxy-2,3-d...

CAS#:320-77-4

Literature: Terasawa, Masato; Takahashi, Joji Agricultural and Biological Chemistry, 1981 , vol. 45, # 11 p. 2433 - 2442

~%

3-carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid Structure

3-carboxy-2,3-d...

CAS#:320-77-4

Literature: Krebs; Holzach Biochemical Journal, 1952 , vol. 52, p. 527 Full Text View citing articles Show Details Friedrich-Freksa; Martius Zeitschrift fuer Naturforschung, 1951 , vol. 6b, p. 296

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3-carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid Structure

3-carboxy-2,3-d...

CAS#:320-77-4

Detail
Literature: Terasawa, Masato; Takahashi, Joji Agricultural and Biological Chemistry, 1981 , vol. 45, # 11 p. 2433 - 2442

~%

3-carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid Structure

3-carboxy-2,3-d...

CAS#:320-77-4

Literature: Oogaki, Masako; Inoue, Madoka; Kaimaktchiev, Atanas C.; Nakahara, Tadaatsu; Tabuchi, Takeshi Agricultural and Biological Chemistry, 1984 , vol. 48, # 3 p. 789 - 796

~%

3-carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid Structure

3-carboxy-2,3-d...

CAS#:320-77-4

Literature: Greenstein Journal of Biological Chemistry, 1936 , vol. 116, p. 463,466 Full Text Show Details Pucher; Vickery Journal of Biological Chemistry, 1946 , vol. 163, p. 181

~%

3-carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid Structure

3-carboxy-2,3-d...

CAS#:320-77-4

Literature: Fittig; Miller Justus Liebigs Annalen der Chemie, 1889 , vol. 255, p. 43,46

 Synonyms

1-hydroxypropane-1,2,3-tricarboxylic acid
1-Hydroxy-propan-1,2,3-tricarbonsaeure
1-hydroxy-propane-1,2,3-tricarboxylic acid
3-Methylsaeure-pentanol-(2)-disaeure
I-CIT
D-isocitrate
isocitrate
1-Hydroxytricarballylic acid
1-Hydroxy-1,2,3-propanetricarboxylic acid
3-Carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid
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