(2R)-2,3-Bis[(2H35)octadecanoyloxy]propyl 2-{tris[(2H3)methyl]ammonio}(2H4)ethyl phosphate

Modify Date: 2024-01-02 17:38:11

(2R)-2,3-Bis[(2H35)octadecanoyloxy]propyl 2-{tris[(2H3)methyl]ammonio}(2H4)ethyl phosphate Structure
(2R)-2,3-Bis[(2H35)octadecanoyloxy]propyl 2-{tris[(2H3)methyl]ammonio}(2H4)ethyl phosphate structure
Common Name (2R)-2,3-Bis[(2H35)octadecanoyloxy]propyl 2-{tris[(2H3)methyl]ammonio}(2H4)ethyl phosphate
CAS Number 326495-40-3 Molecular Weight 873.657
Density N/A Boiling Point N/A
Molecular Formula C44H5D83NO8P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (2R)-2,3-Bis[(2H35)octadecanoyloxy]propyl 2-{tris[(2H3)methyl]ammonio}(2H4)ethyl phosphate


1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d83 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system[1][2].

 Names

Name (2R)-2,3-Bis[(2H35)octadecanoyloxy]propyl 2-{tris[(2H3)methyl]ammonio}(2H4)ethyl phosphate
Synonym More Synonyms

  Biological Activity

Description 1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d83 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[3].
References

[1]. Andrew D Miller. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811.

[2]. Jayesh A Kulkarni, et al. On the role of helper lipids in lipid nanoparticle formulations of siRNA. Nanoscale. 2019 Nov 21;11(45):21733-21739.

[3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

 Chemical & Physical Properties

Molecular Formula C44H5D83NO8P
Molecular Weight 873.657
Exact Mass 873.145752
LogP 13.00

 Synonyms

Ethan-1,1,2,2-d-aminium, 2-[[[(2R)-2,3-bis[(1-oxooctadecyl-2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13,14,14,15,15,16,16,17,17,18,18,18-d)oxy]propoxy]hydroxyphosphinyl]oxy]-N,N,N-tr i(methyl-d)-, inner salt
(2R)-2,3-Bis[(H)octadecanoyloxy]propyl 2-{tris[(H)methyl]ammonio}(H)ethyl phosphate
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