N-piperidine Ibrutinib

Modify Date: 2024-02-08 17:03:43

N-piperidine Ibrutinib Structure
N-piperidine Ibrutinib structure
Common Name N-piperidine Ibrutinib
CAS Number 330785-90-5 Molecular Weight 386.45
Density N/A Boiling Point N/A
Molecular Formula C22H22N6O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of N-piperidine Ibrutinib


BTK ligand 1 (compound 1) is a ligand targeting Bruton’s tyrosine kinase (Btk). BTK ligand 1 can combine with E3 ligase ligand (Ligand for E3 Ligase) through PROTAC Linker to form PROTAC. PROTACs targeting Btk can be used in the study of chronic lymphocytic leukemia (CLL) and other BK cell malignancies[1].

 Names

Name 3-(4-Phenoxyphenyl)-1-(4-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

 N-piperidine Ibrutinib Biological Activity

Description BTK ligand 1 (compound 1) is a ligand targeting Bruton’s tyrosine kinase (Btk). BTK ligand 1 can combine with E3 ligase ligand (Ligand for E3 Ligase) through PROTAC Linker to form PROTAC. PROTACs targeting Btk can be used in the study of chronic lymphocytic leukemia (CLL) and other BK cell malignancies[1].
Related Catalog
References

[1]. Buhimschi AD, et al. Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation. Biochemistry. 2018 Jul 3;57(26):3564-3575.  

 Chemical & Physical Properties

Molecular Formula C22H22N6O
Molecular Weight 386.45
Storage condition -20℃
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