folitixorin
Modify Date: 2024-01-04 11:13:28
folitixorin structure
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Common Name | folitixorin | ||
|---|---|---|---|---|
| CAS Number | 3432-99-3 | Molecular Weight | 457.440 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C20H23N7O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of folitixorinFolitixorin (5,10-methylenetetrahydrofolate) is a cofactor and an analog of leucovorin. Folitixorin is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research[1][2]. |
| Name | (6R)-5,10-methylenetetrahydrofolic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Folitixorin (5,10-methylenetetrahydrofolate) is a cofactor and an analog of leucovorin. Folitixorin is a promising agent for modulation of 5-FU cytotoxicity in adjuvant cancer research[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | 5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate into 5-methyltetrahy-drofolate, which is the major circulating form of folate[3]. |
| In Vivo | A colon adenocarcinoma cell suspension is inoculated intrahepatically in a rodent experimental model. Intravenous 5-FU (30 mg/kg) in combination with Folitixorin (15 mg/kg or 30 mg/kg) is administered after 1, 2, 3, 4 and 7 days. 5-FU in combination with Folitixorin (regardless of folate-dose) eliminats tumor take[1]. |
| References |
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Molecular Formula | C20H23N7O6 |
| Molecular Weight | 457.440 |
| Exact Mass | 457.170990 |
| PSA | 194.97000 |
| LogP | -2.87 |
| Index of Refraction | 1.801 |
| Storage condition | -20°C |
| Precursor 0 | |
|---|---|
| DownStream 2 | |
CAS#:365-07-1
CAS#:5238-86-8| UNII:0SXY5ET48B |
| 5,10-methylenetetrahydrofolate |
| 5,10-Methylenetetrahydrofolic acid |
| folitixorin |
| Tetrahydromethylenefolate |
| L-glutamic acid, N-[4-(3-amino-5,6,6a,7-tetrahydro-1-hydroxyimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]- |
| N-[4-(3-amino-1-hydroxy-5,6,6a,7-tetrahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-L-glutamic acid |
| (2S)-2-[[4-(3-amino-1-oxo-4,5,6,6a,7,9-hexahydroimidazo[1,5-f]pteridin-8-yl)benzoyl]amino]pentanedioic acid |
| L-Glutamic acid, N-[4-(3-amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]- |
| CH2H4folate |
| N5,N10-Methyl-enetetrahydrofolic Acid |
| N-[4-(3-Amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-L-glutamic acid |