Tyrosine kinase-IN-7
Modify Date: 2024-04-09 00:21:10
Tyrosine kinase-IN-7 structure
|
Common Name | Tyrosine kinase-IN-7 | ||
|---|---|---|---|---|
| CAS Number | 345615-74-9 | Molecular Weight | 297.375 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 525.2±45.0 °C at 760 mmHg | |
| Molecular Formula | C16H15N3OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 271.5±28.7 °C | |
Use of Tyrosine kinase-IN-7Tyrosine kinase-IN-7 (compound 13h) is an inhibitor of the tyrosine kinase EGFR. The IC50s for inhibiting EGFR(WT) and EGFR(T790M) are 0.630 μM and 0.956 μM respectively. Tyrosine kinase-IN-7 has antitumor activity against four cancer cell lines (HepG2, HCT-116, MCF-7, and A431) with IC50s of 13.02 μM, 10.14 μM, 12.68 μM, and 47.05 μM, respectively[1]. |
| Name | 4-(5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-ylamino)phenol |
|---|---|
| Synonym | More Synonyms |
| Description | Tyrosine kinase-IN-7 (compound 13h) is an inhibitor of the tyrosine kinase EGFR. The IC50s for inhibiting EGFR(WT) and EGFR(T790M) are 0.630 μM and 0.956 μM respectively. Tyrosine kinase-IN-7 has antitumor activity against four cancer cell lines (HepG2, HCT-116, MCF-7, and A431) with IC50s of 13.02 μM, 10.14 μM, 12.68 μM, and 47.05 μM, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.630 μM (EGFRWT), 0.956 μM (EGFRT790M)[1] |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 525.2±45.0 °C at 760 mmHg |
| Molecular Formula | C16H15N3OS |
| Molecular Weight | 297.375 |
| Flash Point | 271.5±28.7 °C |
| Exact Mass | 297.093567 |
| LogP | 4.89 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.760 |
| Phenol, 4-[(5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-yl)amino]- |
| 4-(5,6,7,8-Tetrahydro[1]benzothieno[2,3-d]pyrimidin-4-ylamino)phenol |