Optovin structure
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Common Name | Optovin | ||
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CAS Number | 348575-88-2 | Molecular Weight | 315.413 | |
Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
Molecular Formula | C15H13N3OS2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of OptovinOptovin is a reversible photoactive TRPA1 activator; stimulates human TRPA1 channels in vitro and enables repeated photoactivation of motor behaviors in wild-type zebrafish (EC50 = 2 μM).IC50 value:Target: in vitro: Optovin is a rhodanine-containing small molecule with no previously annotated biological activity. Whereas DMSO-treated animals do not respond to photic stimuli, optovin-treated animals respond to light with vigorous motor excitation at an EC50 of 2 μM. Optovin-treated animals respond to 387 nm (violet) stimuli, but not to 485 nm (blue), 560 nm (green) or longer wavelengths. optovin strongly activated 33% (35/105) of DRG neurons. optovin acts on a molecular target expressed in mustard oil responsive mammalian DRG sensory neurons; perhaps on TRPA1 itself. TrpA1 is necessary for the optovin response [1].in vivo: Optovin also elicited nociceptive behaviors in adult mice. optovin shows activity on adult animals in vivo, and may be preferable to conventional TRPA1 ligands for achieving high-resolution spatiotemporal control. |
Name | 4-Thiazolidinone, 5-[[2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-2-thioxo- |
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Synonym | More Synonyms |
Description | Optovin is a reversible photoactive TRPA1 activator; stimulates human TRPA1 channels in vitro and enables repeated photoactivation of motor behaviors in wild-type zebrafish (EC50 = 2 μM).IC50 value:Target: in vitro: Optovin is a rhodanine-containing small molecule with no previously annotated biological activity. Whereas DMSO-treated animals do not respond to photic stimuli, optovin-treated animals respond to light with vigorous motor excitation at an EC50 of 2 μM. Optovin-treated animals respond to 387 nm (violet) stimuli, but not to 485 nm (blue), 560 nm (green) or longer wavelengths. optovin strongly activated 33% (35/105) of DRG neurons. optovin acts on a molecular target expressed in mustard oil responsive mammalian DRG sensory neurons; perhaps on TRPA1 itself. TrpA1 is necessary for the optovin response [1].in vivo: Optovin also elicited nociceptive behaviors in adult mice. optovin shows activity on adult animals in vivo, and may be preferable to conventional TRPA1 ligands for achieving high-resolution spatiotemporal control. |
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Related Catalog | |
References |
Density | 1.4±0.1 g/cm3 |
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Molecular Formula | C15H13N3OS2 |
Molecular Weight | 315.413 |
Exact Mass | 315.049988 |
PSA | 104.31000 |
LogP | 2.04 |
Index of Refraction | 1.718 |
Storage condition | -20℃ |
(5Z)-5-{[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene}-2-thioxo-1,3-thiazolidin-4-one |
(5Z)-5-{[2,5-Dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl]methylene}-2-thioxo-1,3-thiazolidin-4-one |
4-Thiazolidinone, 5-[[2,5-dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-2-thioxo-, (5Z)- |
Optovin |