(Asn670,Sta671,Val672)-Amyloid β/A4 Protein Precursor770 (662-675) ammonium salt

Modify Date: 2024-01-04 19:23:12

(Asn670,Sta671,Val672)-Amyloid β/A4 Protein Precursor770 (662-675) ammonium salt structure	Common Name	(Asn670,Sta671,Val672)-Amyloid β/A4 Protein Precursor770 (662-675) ammonium salt
	CAS Number	350228-37-4	Molecular Weight	1651.809
	Density	1.3±0.1 g/cm3	Boiling Point	1976.1±65.0 °C at 760 mmHg
	Molecular Formula	C₇₃H₁₁₈N₁₆O₂₇	Melting Point	N/A
	MSDS	N/A	Flash Point	1148.9±34.3 °C

Use of (Asn670,Sta671,Val672)-Amyloid β/A4 Protein Precursor770 (662-675) ammonium salt

β-Secretase inhibitor ([Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)) is a β-secretase and BACE1 inhibitor (IC50: 25 nM for β-secretase)[1].

Name	h-lys-thr-glu-glu-ile-ser-glu-val-asn-sta-val-ala-glu-phe-oh
Synonym	More Synonyms

Description	β-Secretase inhibitor ([Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)) is a β-secretase and BACE1 inhibitor (IC50: 25 nM for β-secretase)[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase Research Areas >> Neurological Disease
References	[1]. Lin Liu, et al. A colorimetric strategy for assay of protease activity based on gold nanoparticle growth controlled by ascorbic acid and Cu(II)-coordinated peptide. Sensors and Actuators B: Chemical. Volume 266, 1 August 2018, Pages 246-254. [2]. Zhou Y, et al. Tyrosine-Conjugation Method for Evaluating BACE1 Activity Based on Silver Nanoparticles/Metal-Organic Framework Composites as Electrochemical Tags. Chemistry. 2023 May 16;29(28):e202300450.

Description

β-Secretase inhibitor ([Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)) is a β-secretase and BACE1 inhibitor (IC50: 25 nM for β-secretase)[1].

Related Catalog

Signaling Pathways >> Neuronal Signaling >> Beta-secretase

Research Areas >> Neurological Disease

References

[1]. Lin Liu, et al. A colorimetric strategy for assay of protease activity based on gold nanoparticle growth controlled by ascorbic acid and Cu(II)-coordinated peptide. Sensors and Actuators B: Chemical. Volume 266, 1 August 2018, Pages 246-254.

[2]. Zhou Y, et al. Tyrosine-Conjugation Method for Evaluating BACE1 Activity Based on Silver Nanoparticles/Metal-Organic Framework Composites as Electrochemical Tags. Chemistry. 2023 May 16;29(28):e202300450.

Density	1.3±0.1 g/cm3
Boiling Point	1976.1±65.0 °C at 760 mmHg
Molecular Formula	C₇₃H₁₁₈N₁₆O₂₇
Molecular Weight	1651.809
Flash Point	1148.9±34.3 °C
Exact Mass	1650.835205
PSA	720.62000
LogP	-2.42
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.562

L-Aspartamide, L-lysyl-L-threonyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-seryl-L-α-glutamyl-L-valyl-N-[(1S,2S,6S,9S,12S,15S)-15-carboxy-12-(2-carboxyethyl)-2-hydroxy-9-methyl-6-(1-meth ylethyl)-1-(2-methylpropyl)-4,7,10,13-tetraoxo-16-phenyl-5,8,11,14-tetraazahexadec-1-yl]-

L-Aspartamide, L-lysyl-L-threonyl-L-α-glutamyl-L-α-glutamyl-L-isoleucyl-L-seryl-L-α-glutamyl-L-valyl-N-[(1S,2S,6S,9S,12S,15S)-15-carboxy-12-(2-carboxyethyl)-2-hydroxy-9-methyl-6-(1-methylethyl)-1-(2-methylpropyl)-4,7,10,13-tetraoxo-16-phenyl-5,8,11,14-tetraazahexadec-1-yl]-

(2S,5S,8S,11S,15S,16S,19S,22S,25S,28S,31S,34S,37S)-19-(2-Amino-2-oxoethyl)-2-benzyl-31-[(2S)-butan-2-yl]-5,25,34-tris(2-carboxyethyl)-37-{[(2S,3R)-2-{[(2S)-2,6-diaminohexanoyl]amino}-3-hydroxybutanoyl]amino}-15-hydroxy-28-(hydroxymethyl)-16-isobutyl-11,22-diisopropyl-8-methyl-4,7,10,13,18,21,24,27,30,33,36-undecaoxo-3,6,9,12,17,20,23,26,29,32,35-undecaazatetracontane-1,40-dioic acid (non-preferred name)

kteeisevn-sta-vaef

b-secretase inhibitor

(2S,5S,8S,11S,15S,16S,19S,22S,25S,28S,31S,34S,37S)-19-(2-Amino-2-oxoethyl)-2-benzyl-31-[(2S)-2-butanyl]-5,25,34-tris(2-carboxyethyl)-37-{[(2S,3R)-2-{[(2S)-2,6-diaminohexanoyl]amino}-3-hydroxybutanoyl]amino}-15-hydroxy-28-(hydroxymethyl)-16-isobutyl-11,22-diisopropyl-8-methyl-4,7,10,13,18,21,24,27,30,33,36-undecaoxo-3,6,9,12,17,20,23,26,29,32,35-undecaazatetracontane-1,40-dioic acid (non-preferred name)

KTEEISEVN-Sta-VAEF(Sta=statine)

(Asn670,Sta671,Val672)-Amyloid β/A4 Protein Precursor770 (662-675)

GL Biochem (Shanghai) Ltd.
China
Product Name: KTEEISEVN-Sta-VAEF(Sta=statine)
Price: $Inquiry/1kg
Purity: 98.0%
Delivery: Inquiry
Contact: Jackie Yang
Email: ymbetter@glbiochem.com

Nanjing Peptide Biotech Ltd
China
Product Name: L-Lysyl-L-threonyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-seryl-L-alpha-glutamyl-L-valyl-L-asparaginyl-(3S,4S)-4-amino-3-hydroxy-6-
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Delivery: 7 Day
Contact: jom
Email: chenglong.fan@njpeptide.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: H-LYS-THR-GLU-GLU-ILE-SER-GLU-VAL-ASN-STA-VAL-ALA-GLU-PHE-OH
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Taiwan Oyi peptide Co. Ltd
China
Product Name: (Asn670,Sta671,Val672)-Amyloid β/A4 Protein Precursor770 (662-675) ammonium salt
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Delivery: 1 Day
Contact: Vinnie
Email: Jamie@api-made.com

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(Asn670,Sta671,Val672)-Amyloid β/A4 Protein Precursor770 (662-675) ammonium salt

Use of (Asn670,Sta671,Val672)-Amyloid β/A4 Protein Precursor770 (662-675) ammonium salt

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