Amphotericin B methyl ester hydrochloride

Modify Date: 2026-07-02 17:25:17

Amphotericin B methyl ester hydrochloride structure	Common Name	Amphotericin B methyl ester hydrochloride
	CAS Number	35375-29-2	Molecular Weight	974.56700
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₈H₇₆ClNO₁₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Amphotericin B methyl ester hydrochloride

Amphotericin B methyl ester hydrochloride is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B methyl ester hydrochloride is the cholesterol-binding compound possesses significant antifungal activity. Amphotericin B methyl ester hydrochloride disrupts HIV-1 particle production and potently inhibits HIV-1 replication[1][2].

Name	methyl (1S,3R,4E,6E,8E,10E,12E,14E,16E,18S,19R,20R,21S,25R,27R,30R,31R,33S,35R,37S,38R)-3-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-19,25,27,30,31,33,35,37-octahydroxy-18,20,21-trimethyl-23-oxo-22,39-dioxabicyclo[33.3.1]nonatriaconta-4
Synonym	More Synonyms

Description	Amphotericin B methyl ester hydrochloride is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B methyl ester hydrochloride is the cholesterol-binding compound possesses significant antifungal activity. Amphotericin B methyl ester hydrochloride disrupts HIV-1 particle production and potently inhibits HIV-1 replication[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	Amphotericin B methyl ester hydrochloride inhibits HIV-1 particle production with no significant effect on Gag binding to the plasma membrane, Gag association with lipid rafts, or Gag multimerization[1].
References	[1]. Waheed AA, et al. Inhibition of human immunodeficiency virus type 1 assembly and release by the cholesterol-binding compound amphotericin B methyl ester: evidence for Vpu dependence. J Virol. 2008 Oct;82(19):9776-81. [2]. Keim GR, et al. Comparative toxicological studies of amphotericin B methyl ester and amphotericin B in mice, rats, and dogs. ntimicrob Agents Chemother. 1976 Oct;10(4):687-90.

Molecular Formula	C₄₈H₇₆ClNO₁₇
Molecular Weight	974.56700
Exact Mass	973.48000
PSA	308.61000
LogP	2.30240
InChIKey	FCUABMXRRQIKMV-MFVSQRFRSA-N
SMILES	COC(=O)C1C(O)CC2(O)CC(O)CC(O)C(O)CCC(O)CC(O)CC(=O)OC(C)C(C)C(O)C(C)C=CC=CC=CC=CC=CC=CC=CC(OC3OC(C)C(O)C(N)C3O)CC1O2.Cl

Amphotericin B,methyl ester,hydrochloride

AME hydrochloride

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Amphotericin B methyl ester hydrochloride

Use of Amphotericin B methyl ester hydrochloride

Names

Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.