ESTRADIOL HEMIHYDRATE

Modify Date: 2024-01-02 17:36:56

ESTRADIOL HEMIHYDRATE structure	Common Name	ESTRADIOL HEMIHYDRATE
	CAS Number	35380-71-3	Molecular Weight	562.779
	Density	N/A	Boiling Point	445.9ºC at 760mmHg
	Molecular Formula	C₁₈H₂₆O₃	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	209.6ºC
	Symbol	GHS08	Signal Word	Danger

Use of ESTRADIOL HEMIHYDRATE

Estradiol (β-Estradiol) hemihydrate is a steroid hormone and the major female sex hormone. Estradiol (β-Estradiol) hemihydrate can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol (β-Estradiol) hemihydrate can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering[1][2].

Name	(8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol,hydrate
Synonym	More Synonyms

Description	Estradiol (β-Estradiol) hemihydrate is a steroid hormone and the major female sex hormone. Estradiol (β-Estradiol) hemihydrate can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol (β-Estradiol) hemihydrate can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering[1][2].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer Research Areas >> Neurological Disease
In Vitro	Estradiol hemihydrate (10 nM, 7 days) induces neural differentiation and increased neurite branching of human endometrial stem cells (hEnSCs)[1]. Estradiol hemihydrate (17β-estradiol, 10 nM, 7 days) increases the expression of neuron-like cell markers (Tuj-1, nestin and NF-H) in neural-like cells differentiated from hEnSCs[1]. Cell Differentiation Assay[1] Cell Line: Isolated human endometrial stem cells (hEnSCs) from human endometrial tissue Concentration: 10 nM Incubation Time: 7 days Result: Increased the percentage of neural marker (Tuj-1, nestin and NF-H)-positive cells of 62.2±1.3%, 71.5±4% and 51.2±1.5% respectively. Immunofluorescence[1] Cell Line: Isolated human endometrial stem cells (hEnSCs) from human endometrial tissue Concentration: 10 nM Incubation Time: 7 days Result: Increased the percentage of neural marker (Tuj-1, nestin and NF-H)-positive cells of 62.2±1.3%, 71.5±4% and 51.2±1.5% respectively.
In Vivo	Estradiol hemihydrate (1 nM, the hippocampal slices from FBN-ARO-KO mice) rescues long-term potentiation (LTP) amplitude[1]. Estradiol hemihydrate (0.0167 mg, implanted s.c., FBN-ARO-KO mice) rescues the molecular and functional deficits in FBN-ARO-KO mice[1]. Animal Model: FBN-ARO-KO Mice[2] Dosage: 1 nM Administration: Treated for the hippocampal slices Result: Rescued long-term potentiation (LTP) amplitude of both male and female mice. Animal Model: FBN-ARO-KO Mice[2] Dosage: 0.0167 mg Administration: Alzet minipumps with Estradiol (implanted s.c.), examined 7 days after minipump implantation. Result: Restored hippocampal and cortical E2 levels to 93%, phosphorylation of AKT, ERK and CREB in the hippocampus and cortex to 90-95%, BDNF level to 80-90%, restored both synaptophysin and PSD95 in the forebrain. Rescued the spatial learning and memory defects.
References	[1]. Elham Hasanzadeh. Defining the role of 17β-estradiol in human endometrial stem cells differentiation into neuron-like cells. Cell Biol Int. 2021 Jan;45(1):140-153. [2]. Yujiao Lu, et al. Neuron-Derived Estrogen Regulates Synaptic Plasticity and Memory. J Neurosci. 2019 Apr 10;39(15):2792-2809.

Boiling Point	445.9ºC at 760mmHg
Molecular Formula	C₁₈H₂₆O₃
Molecular Weight	562.779
Flash Point	209.6ºC
Exact Mass	562.365845
PSA	49.69000
LogP	3.54490

ESTRADIOL HEMIHYDRATE MSDS(Chinese)

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H351-H360Fd-H362
Precautionary Statements	P201-P263-P281-P308 + P313
Personal Protective Equipment	Eyeshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T
Risk Phrases	60-63-40-64
Safety Phrases	53-36/37-45
RIDADR	NONH for all modes of transport

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(17β)-Estra-1,3,5(10)-triene-3,17-diol hydrate (2:1)

ESTRADIOL HEMIHYDRATE

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Estra-1,3,5(10)-triene-3,17-diol, (17β)-, hydrate (2:1)

Estra-1,3,5(10)-triene-3,17β-diol hydrate (2:1)

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