ZINC02092166
Modify Date: 2025-11-27 21:09:56
ZINC02092166 structure
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Common Name | ZINC02092166 | ||
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| CAS Number | 354543-09-2 | Molecular Weight | 349.264 | |
| Density | 2.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C14H7N9O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ZINC02092166ZINC02092166 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 1.7 and 7.0 uM in AlphaScreen and FP assay (wild-type β-catenin), respectively; remain affinity for muant catenin V511S, V511S/I569S and R469A with Ki of 20-50 uM; exhibits dual selectivity for β-catenin/Tcf over β-catenin/cadherin and β-catenin/APC PPIs. |
| Name | 4-Amino-N'-[(9Z)-9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-ylidene]-1,2,5-oxadiazole-3-carbohydrazide |
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| Synonym | More Synonyms |
| Description | ZINC02092166 is a novel potent, and selective small-molecule inhibitor for the β-catenin/Tcf4 protein-protein interaction with Ki of 1.7 and 7.0 uM in AlphaScreen and FP assay (wild-type β-catenin), respectively; remain affinity for muant catenin V511S, V511S/I569S and R469A with Ki of 20-50 uM; exhibits dual selectivity for β-catenin/Tcf over β-catenin/cadherin and β-catenin/APC PPIs. |
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| References | References 1. Catrow JL, et al. J Med Chem. 2015 Jun 11;58(11):4678-92. View Related Products by Target Beta-catenin |
| Density | 2.2±0.1 g/cm3 |
|---|---|
| Molecular Formula | C14H7N9O3 |
| Molecular Weight | 349.264 |
| Exact Mass | 349.067200 |
| LogP | 2.05 |
| Index of Refraction | 2.082 |
| InChIKey | VQFGZNKRRJEBMK-UHFFFAOYSA-N |
| SMILES | Nc1nonc1C(=O)N=Nc1c2ccccc2c2nc3no[nH]c3nc12 |
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| 4-Amino-N'-[(9Z)-9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-ylidene]-1,2,5-oxadiazole-3-carbohydrazide |
| 1,2,5-Oxadiazole-3-carboxylic acid, 4-amino-, 2-[(9Z)-9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-ylidene]hydrazide |