Formic acid,2-[4-(5-nitro-2-furanyl)-2-thiazolyl]hydrazide

Modify Date: 2026-08-24 16:19:39

Formic acid,2-[4-(5-nitro-2-furanyl)-2-thiazolyl]hydrazide Structure
Formic acid,2-[4-(5-nitro-2-furanyl)-2-thiazolyl]hydrazide structure
 Common Name Formic acid,2-[4-(5-nitro-2-furanyl)-2-thiazolyl]hydrazide
CAS Number 3570-75-0 Molecular Weight 254.22300
Density 1.612g/cm3 Boiling Point 454.8ºC at 760mmHg
Molecular Formula C8H6N4O4S Melting Point 215.5ºC (DECOMP)
MSDS N/A Flash Point 228.9ºC

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.612g/cm3
Boiling Point 454.8ºC at 760mmHg
Melting Point 215.5ºC (DECOMP)
Molecular Formula C8H6N4O4S
Molecular Weight 254.22300
Flash Point 228.9ºC
Exact Mass 254.01100
PSA 141.22000
LogP 3.00720
Index of Refraction 1.679
InChIKey DUWYZHLZDVCZIO-UHFFFAOYSA-N
SMILES O=CNNc1nc(-c2ccc([N+](=O)[O-])o2)cs1

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LQ9275000
CHEMICAL NAME :
Formic acid, 2-(4-(5-nitro-2-furyl)-2-thiazolyl)hydrazide
CAS REGISTRY NUMBER :
3570-75-0
LAST UPDATED :
199801
DATA ITEMS CITED :
26
MOLECULAR FORMULA :
C8-H6-N4-O4-S
MOLECULAR WEIGHT :
254.24
WISWESSER LINE NOTATION :
T5OJ BNW E- ET5N CSJ BMMVH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1400 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - muscle contraction or spasticity
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
445 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Behavioral - muscle contraction or spasticity
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10500 mg/kg/3W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10500 mg/kg/3W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
31 gm/kg/44W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
30 gm/kg/33W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Blood - leukemia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
22 gm/kg/48W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Kidney, Ureter, Bladder - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
48 gm/kg/29W
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Blood - leukemia
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
28 gm/kg/33W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Blood - leukemia
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
41 gm/kg/49W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - Kidney tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
28 gm/kg/46W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
38640 mg/kg/46W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
1575 mg/kg/5D (Intermittent)
REFERENCE :
CMMUAO Chemical Mutagens. Principles and Methods for Their Detection. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1971- Volume(issue)/page/year: 5,257,1978 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 7,151,1974 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 7,151,1974 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971 TOXICOLOGY REVIEW CCSUDL Carcinogenesis--A Comprehensive Survey. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) V.1- 1976- Volume(issue)/page/year: 4,171,1978

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

HS Code 2934100090

 Precursor & DownStream

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor  4

DownStream  0

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2934100090
Summary 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

 Bioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Carcinogenic activity on breast after oral administration
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL770576
Name: Carcinogenic activity on all sites after oral administration
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL770414
Name: Carcinogenic activity on liver after oral administration of the compound
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL771452
Name: Carcinogenic activity on other sites after oral administration
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL772506
Name: Anticarcinogenic activity in rat assessed as induction of tumors per day
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL932489
Name: Carcinogenic activity on ear duct after oral administration of the compound; - denote...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL771651
Name: Carcinogenesis bioassays from the Carcinogenic Potency Database (CPDB)
Source: 25294
Target: N/A
External Id: cpdb
Total 7, Current Page 1 of 1
1

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Nifurthiazole [USAN:INN]
NIFURTHIAZOLE
Nifurthiazol
formic acid N'-[4-(5-nitro-furan-2-yl)-thiazol-2-yl]-hydrazide
2-<2-Formylhydrazino>-4-<5-nitro-2-furyl>-thiazol
Nifurtiazol [INN-Spanish]
2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole
Nifurthiazolum [INN-Latin]
Nefurthiazole

  | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the upstream materials of N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide?
A: Related upstream materials(CAS) of N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide: 15057-21-3;18523-69-8;64-18-6;26049-68-3.
Q: What is the InChIKey of N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide?
A: InChIKey of N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide is DUWYZHLZDVCZIO-UHFFFAOYSA-N.
Q: What is the melting point of N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide?
A: Melting point of N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide is 215.5ºC (DECOMP).
Q: What is the CAS number of N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide?
A: CAS number of N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide is 3570-75-0.
Q: What is the SMILES notation of N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide?
A: SMILES notation of N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide is O=CNNc1nc(-c2ccc([N+](=O)[O-])o2)cs1.
Q: What is the polar surface area (PSA) of N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide?
A: Polar surface area (PSA) of N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide is 141.22000.
Q: What is the LogP of N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide?
A: LogP of N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide is 3.00720.
Q: What English synonyms does N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide have?
A: English synonyms of N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide: Nifurthiazole [USAN:INN], NIFURTHIAZOLE, Nifurthiazol, formic acid N'-[4-(5-nitro-furan-2-yl)-thiazol-2-yl]-hydrazide, 2--4--thiazol, Nifurtiazol [INN-Spanish], 2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole, Nifurthiazolum [INN-Latin], Nefurthiazole.
Q: What is the molecular weight of N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide?
A: Molecular weight of N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide is 254.22300.
Q: What is the English name of N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide?
A: The English name of N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide is N-[[4-(5-nitrofuran-2-yl)-1,3-thiazol-2-yl]amino]formamide.

 factory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Dayang Chem (Hangzhou) Co., Ltd.
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Chemsrc provides CAS#:3570-75-0 MSDS, density, melting point, boiling point, structure, etc. Its name is Formic acid,2-[4-(5-nitro-2-furanyl)-2-thiazolyl]hydrazide>> amp version: Formic acid,2-[4-(5-nitro-2-furanyl)-2-thiazolyl]hydrazide

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