Tocainide HCl

Modify Date: 2024-01-21 10:55:49

Tocainide HCl Structure
Tocainide HCl structure
Common Name Tocainide HCl
CAS Number 35891-93-1 Molecular Weight 228.71800
Density N/A Boiling Point 330.1ºC at 760 mmHg
Molecular Formula C11H17ClN2O Melting Point 244-245 °C
MSDS N/A Flash Point 153.5ºC

 Names

Name Tocainide hydrochloride
Synonym More Synonyms

 Chemical & Physical Properties

Boiling Point 330.1ºC at 760 mmHg
Melting Point 244-245 °C
Molecular Formula C11H17ClN2O
Molecular Weight 228.71800
Flash Point 153.5ºC
Exact Mass 228.10300
PSA 55.12000
LogP 3.16440
Storage condition -20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TX1404500
CHEMICAL NAME :
Propanamide, 2-amino-N-(2,6-dimethylphenyl)-, monohydrochloride
CAS REGISTRY NUMBER :
35891-93-1
LAST UPDATED :
199706
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C11-H16-N2-O.Cl-H
MOLECULAR WEIGHT :
228.75

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
48 mg/kg/2D-I
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
REFERENCE :
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925- Volume(issue)/page/year: 61,79,1985
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
257 mg/kg/15D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Taste) - change in function Behavioral - tremor Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969- Volume(issue)/page/year: 22,142,1988
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
360 mg/kg/6W-I
TOXIC EFFECTS :
Blood - normocytic anemia Blood - agranulocytosis
REFERENCE :
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 147,598,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
529 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 15,192,1973

 Synonyms

Xylotocan
Unii-2K7I38ckn5
tonocardhydrochloride
TOCAINIDE HCL