propiomazine

Modify Date: 2025-08-23 13:04:08

propiomazine Structure
propiomazine structure
Common Name propiomazine
CAS Number 362-29-8 Molecular Weight 340.48200
Density 1.137g/cm3 Boiling Point 500.8ºC at 760mmHg
Molecular Formula C20H24N2OS Melting Point N/A
MSDS N/A Flash Point 256.7ºC

 Use of propiomazine


Propiomazine is an orally active antihistamine agent with sedative effects. Propiomazine can be used in the research of insomnia[1][2].

 Names

Name propiomazine
Synonym More Synonyms

 propiomazine Biological Activity

Description Propiomazine is an orally active antihistamine agent with sedative effects. Propiomazine can be used in the research of insomnia[1][2].
Related Catalog
In Vivo Propiomazine (0.2 mg/kg, nasal administration, rats) is quickly absorbed, followed by rapid reduction of the plasma concentrations[3]. Propiomazine (25 mg/kg, i.p., at 0 and 3 h after challenge) protects rats against CCl4-induced hepatic injury[4]. Propiomazine (0.31-20 mg/kg, i.v.) increases plasma prolactin concentrations in rats[5].

 Chemical & Physical Properties

Density 1.137g/cm3
Boiling Point 500.8ºC at 760mmHg
Molecular Formula C20H24N2OS
Molecular Weight 340.48200
Flash Point 256.7ºC
Exact Mass 340.16100
PSA 48.85000
LogP 4.89710
InChIKey UVOIBTBFPOZKGP-UHFFFAOYSA-N
SMILES CCC(=O)c1ccc2c(c1)N(CC(C)N(C)C)c1ccccc1S2

 Synthetic Route

~%

propiomazine Structure

propiomazine

CAS#:362-29-8

Literature: Bulletin de la Societe Chimique de France, , p. 1474,1480

 Precursor & DownStream

Precursor  1

DownStream  0

 propiomazineBioassay

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Name: Compound was evaluated for inhibition of rat Gabra1 in an in vitro assay with cellula...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-1
External Id: CHEMBL5291801
Name: Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-1
External Id: CHEMBL5291798
Name: Binding affinity towards human ESR1 in an in vitro cell free assay (NIBR assay) measu...
Source: ChEMBL
Target: Estrogen receptor
External Id: CHEMBL5291791
Name: Binding affinity towards human HRH3 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Histamine H3 receptor
External Id: CHEMBL5291921
Name: Binding affinity towards human DRD2 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: D(2) dopamine receptor
External Id: CHEMBL5291781
Name: Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resol...
Source: ChEMBL
Target: D(1A) dopamine receptor
External Id: CHEMBL5291777
Name: Binding affinity towards human CHRM2 in an in vitro assay with cellular components me...
Source: ChEMBL
Target: Muscarinic acetylcholine receptor M2
External Id: CHEMBL5291900
Name: Binding affinity towards human DRD3 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: D(3) dopamine receptor
External Id: CHEMBL5291899
Name: Binding affinity towards human CNR1 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Cannabinoid receptor 1
External Id: CHEMBL5291773
Name: Binding affinity towards human MC4R in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Melanocortin receptor 4
External Id: CHEMBL5291832
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 Synonyms

Propiomazinum
1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one
Propiomazinum [INN-Latin]
Propiomazina [INN-Spanish]
Wy-1359
Largon
Dorevan
Phenoctyl
1-[10-(2-dimethylamino-propyl)-10H-phenothiazin-2-yl]-propan-1-one
Propionylpromethazine
Propiomazina
1-[10-(2-dimethylamino-propyl)-phenothiazin-2-yl]-propan-1-one
10-<2-Dimethylamino-propyl>-3-propionyl-phenothiazin
3-Propionyl-10-<2-dimethylamino-propyl>-phenothiazin
1-[10-(2-Dimethylamino-propyl)-phenothiazin-2-yl]-propan-1-on
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