Cephalotaxine,3-[4-methyl (2R)-2-hydroxy-2-(3-methylbutyl)butanedioate]

Modify Date: 2024-01-04 16:56:40

Cephalotaxine,3-[4-methyl (2R)-2-hydroxy-2-(3-methylbutyl)butanedioate] structure	Common Name	Cephalotaxine,3-[4-methyl (2R)-2-hydroxy-2-(3-methylbutyl)butanedioate]
	CAS Number	36804-95-2	Molecular Weight	515.59500
	Density	1.3g/cm3	Boiling Point	645.8ºC at 760mmHg
	Molecular Formula	C₂₈H₃₇NO₈	Melting Point	N/A
	MSDS	N/A	Flash Point	344.4ºC

Use of Cephalotaxine,3-[4-methyl (2R)-2-hydroxy-2-(3-methylbutyl)butanedioate]

Deoxyharringtonine is an alkaloid isolated from Cephalotaxus genus with significant anti-leukemic activity[1].

Name	deoxyharringtonine
Synonym	More Synonyms

Description	Deoxyharringtonine is an alkaloid isolated from Cephalotaxus genus with significant anti-leukemic activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Deoxyharringtonine 作用于 P388 白血病细胞的 IC50 值为 7.5 ng/mL。此外，其对造血细胞系如 HL-60、HL-60/RV+、JURKAT、ALL3、NCEB1、JEKO、MOLT-3 等具有极强的细胞毒活性[1]。
References	[1]. Joseph D Eckelbarger, et al. Synthesis of antiproliferative Cephalotaxus esters and their evaluation against several human hematopoietic and solid tumor cell lines: uncovering differential susceptibilities to multidrug resistance. Chemistry. 2008;14(14):4293-306.

Density	1.3g/cm3
Boiling Point	645.8ºC at 760mmHg
Molecular Formula	C₂₈H₃₇NO₈
Molecular Weight	515.59500
Flash Point	344.4ºC
Exact Mass	515.25200
PSA	103.76000
LogP	3.01360
Index of Refraction	1.595

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FK0279000

CHEMICAL NAME :: Cephalotaxine, 4-methyl-, 2-hydroxy-2-(3-methylbutyl)butanedioate (ester), (3(R))-

CAS REGISTRY NUMBER :: 36804-95-2

LAST UPDATED :: 199209

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C28-H37-N-O8

MOLECULAR WEIGHT :: 515.66

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 16 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 24,1,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 24,1,1988

(-)-deoxyharringtonine

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