MitoBloCK 1
Modify Date: 2024-09-18 18:22:55
MitoBloCK 1 structure
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Common Name | MitoBloCK 1 | ||
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| CAS Number | 373370-73-1 | Molecular Weight | 368.249 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 513.1±60.0 °C at 760 mmHg | |
| Molecular Formula | C14H14BrN3O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 264.1±32.9 °C | |
Use of MitoBloCK 1MitoBloCK 1 is a small molecule inhibitor that blocks the import of substrates that use the TIM22 import pathway, but not TIM23 or the Mia40/Erv1 translocation pathways; also inhibits growth of mammalian cells and import of the ADP/ATP carrier, but not TIM23 substrates; an useful chemical tool for investigation mammalian mitochondrial import and dysfunction linked to inherited human disease. |
| Name | (2E)-2-[(3-Bromo-2-hydroxy-6,7,8,9-tetrahydrodibenzo[b,d]furan-1-yl)methylene]hydrazinecarbothioamide |
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| Synonym | More Synonyms |
| Description | MitoBloCK 1 is a small molecule inhibitor that blocks the import of substrates that use the TIM22 import pathway, but not TIM23 or the Mia40/Erv1 translocation pathways; also inhibits growth of mammalian cells and import of the ADP/ATP carrier, but not TIM23 substrates; an useful chemical tool for investigation mammalian mitochondrial import and dysfunction linked to inherited human disease. |
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| References | References 1. Hasson SA, et al. Proc Natl Acad Sci U S A. 2010 May 25;107(21):9578-83. View Related Products by Target Other Targets |
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Boiling Point | 513.1±60.0 °C at 760 mmHg |
| Molecular Formula | C14H14BrN3O2S |
| Molecular Weight | 368.249 |
| Flash Point | 264.1±32.9 °C |
| Exact Mass | 366.998993 |
| LogP | 5.15 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.769 |
| InChIKey | VBDLLTJWFFBEAG-UHFFFAOYSA-N |
| SMILES | NC(=S)NN=Cc1c(O)c(Br)cc2oc3c(c12)CCCC3 |
| Hydrazinecarbothioamide, 2-[(3-bromo-6,7,8,9-tetrahydro-2-hydroxy-1-dibenzofuranyl)methylene]-, (2E)- |
| (2E)-2-[(3-Bromo-2-hydroxy-6,7,8,9-tetrahydrodibenzo[b,d]furan-1-yl)methylene]hydrazinecarbothioamide |