CEP-8983
CEP-8983 structure
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Common Name | CEP-8983 | ||
|---|---|---|---|---|
| CAS Number | 374071-46-2 | Molecular Weight | 306.31500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H14N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CEP-8983CEP-8983 is a PARP-1 and PARP-2 inhibitor (IC50: 20 and 6 nM). CEP-8983 is an effective chemosensitizing agent, and can sensitize chemotherapy-resistant cell lines and subcutaneous xenografts to Temozolomide (HY-17364) and Camptothecin (HY-16560)[1]. |
| Name | 4,5,6,7-tetrahydro-11-methoxy-1H-cyclopenta[a]pyrrolo[3,4-c]carbazole-1,3(2H)dione |
|---|---|
| Synonym | More Synonyms |
| Description | CEP-8983 is a PARP-1 and PARP-2 inhibitor (IC50: 20 and 6 nM). CEP-8983 is an effective chemosensitizing agent, and can sensitize chemotherapy-resistant cell lines and subcutaneous xenografts to Temozolomide (HY-17364) and Camptothecin (HY-16560)[1]. |
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| Related Catalog | |
| Target |
20 and 6 nM (PARP-1/2)[1]. |
| References |
| Molecular Formula | C18H14N2O3 |
|---|---|
| Molecular Weight | 306.31500 |
| Exact Mass | 306.10000 |
| PSA | 74.68000 |
| LogP | 2.71240 |
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CEP-8983 CAS#:374071-46-2 |
| Literature: CEPHALON, INC.; BIERLMAIER, Stephen; CHRISTIE, Michael; COURVOISIER, Laurent; FIELD, R. Scott; HALTIWANGER, R. Curtis; HE, Linli; JACOBS, Martin J.; KRESS, Michael; MCKEAN, Robert E.; MOWREY, Dale R.; PETRAITIS, Joseph; YAZDANIAN, Mehran Patent: WO2011/28580 A1, 2011 ; |
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CEP-8983 CAS#:374071-46-2 |
| Literature: CEPHALON, INC.; BIERLMAIER, Stephen; CHRISTIE, Michael; COURVOISIER, Laurent; FIELD, R. Scott; HALTIWANGER, R. Curtis; HE, Linli; JACOBS, Martin J.; KRESS, Michael; MCKEAN, Robert E.; MOWREY, Dale R.; PETRAITIS, Joseph; YAZDANIAN, Mehran Patent: WO2011/28580 A1, 2011 ; |
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CEP-8983 CAS#:374071-46-2 |
| Literature: CEPHALON, INC.; BIERLMAIER, Stephen; CHRISTIE, Michael; COURVOISIER, Laurent; FIELD, R. Scott; HALTIWANGER, R. Curtis; HE, Linli; JACOBS, Martin J.; KRESS, Michael; MCKEAN, Robert E.; MOWREY, Dale R.; PETRAITIS, Joseph; YAZDANIAN, Mehran Patent: WO2011/28580 A1, 2011 ; Location in patent: Page/Page column 19; 24 ; |
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CEP-8983 CAS#:374071-46-2 |
| Literature: CEPHALON, INC.; BIERLMAIER, Stephen; CHRISTIE, Michael; COURVOISIER, Laurent; FIELD, R. Scott; HALTIWANGER, R. Curtis; HE, Linli; JACOBS, Martin J.; KRESS, Michael; MCKEAN, Robert E.; MOWREY, Dale R.; PETRAITIS, Joseph; YAZDANIAN, Mehran Patent: WO2011/28580 A1, 2011 ; |
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CEP-8983 CAS#:374071-46-2 |
| Literature: CEPHALON, INC.; BIERLMAIER, Stephen; CHRISTIE, Michael; COURVOISIER, Laurent; FIELD, R. Scott; HALTIWANGER, R. Curtis; HE, Linli; JACOBS, Martin J.; KRESS, Michael; MCKEAN, Robert E.; MOWREY, Dale R.; PETRAITIS, Joseph; YAZDANIAN, Mehran Patent: WO2011/28580 A1, 2011 ; |
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CEP-8983 CAS#:374071-46-2 |
| Literature: CEPHALON, INC.; BIERLMAIER, Stephen; CHRISTIE, Michael; COURVOISIER, Laurent; FIELD, R. Scott; HALTIWANGER, R. Curtis; HE, Linli; JACOBS, Martin J.; KRESS, Michael; MCKEAN, Robert E.; MOWREY, Dale R.; PETRAITIS, Joseph; YAZDANIAN, Mehran Patent: WO2011/28580 A1, 2011 ; |
![3a,3b,4,5,6,6a,7,11c-octahydro-11-methoxy-1H-cyclopenta[a]pyrrolo[3,4-c]carbazole-1,3(2H)-dione structure](https://image.chemsrc.com/caspic/298/1269629-15-3.png)
| 7-methoxy-1,2,3,11-tetrahydro-5,11-diaza-benzo[a]trindene-4,6-dione |
| 1H-Cyclopenta(a)pyrrolo(3,4-c)carbazole-1,3(2H)-dione,4,5,6,7-tetrahydro-11-methoxy |