Nepodin

Modify Date: 2024-01-10 14:22:09

Nepodin Structure
Nepodin structure
 Common Name Nepodin
CAS Number 3785-24-8 Molecular Weight 216.233
Density 1.3±0.1 g/cm3 Boiling Point 413.2±40.0 °C at 760 mmHg
Molecular Formula C13H12O3 Melting Point 165-166℃ (methanol )
MSDS N/A Flash Point 217.8±23.8 °C

 Use of Nepodin


Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus[1].Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK[2].Nepodin (Musizin) has antidiabetic and antimalarial activities.

 Names

Name 1-(1,8-dihydroxy-3-methylnaphthalen-2-yl)ethanone
Synonym More Synonyms

 Nepodin Biological Activity

Description Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus[1].Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK[2].Nepodin (Musizin) has antidiabetic and antimalarial activities.
Related Catalog
In Vitro Nepodin (Musizin) exhibits significant IC50 values that are 0.74 and 0.79 μg/ml against P. falciparum chloroquine-sensitive (3D7) and P. falciparum chloroquine-resistant (S20), respectively[1].
In Vivo Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner[2]. Animal Model: C57BL/KsJ-db/db mice[2] Dosage: 2 mg/kg; 10 mg/kg Administration: Orally administration; 2-10 mg/kg; 4 weeks Result: Had antihyperglycemic potential and improved insulin resistance.
References

[1]. Lee KH, et al. Antimalarial activity of nepodin isolated from Rumex crispus. Arch Pharm Res. 2013 Apr;36(4):430-5.

[2]. Ha BG, et al. Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo. Biofactors. 2014 Jul-Aug;40(4):436-47.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 413.2±40.0 °C at 760 mmHg
Melting Point 165-166℃ (methanol )
Molecular Formula C13H12O3
Molecular Weight 216.233
Flash Point 217.8±23.8 °C
Exact Mass 216.078644
PSA 57.53000
LogP 2.87
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.668

 Safety Information

HS Code 2914400090

 Synthetic Route

1-(1-hydroxy-8-methoxy-3-methylnaphthalen-2-yl)ethanone structure

1-(1-hydroxy-8-...

CAS#:92190-16-4

~87%

Nepodin Structure

Nepodin

CAS#:3785-24-8

Literature: Rizzacasa, Mark A.; Sargent, Melvyn V. Australian Journal of Chemistry, 1988 , vol. 41, # 7 p. 1087 - 1097
1-Acetoxy-8-methoxy-3-methyl-naphthalin structure

1-Acetoxy-8-met...

CAS#:33471-50-0

~%

Nepodin Structure

Nepodin

CAS#:3785-24-8

Literature: Rizzacasa, Mark A.; Sargent, Melvyn V. Australian Journal of Chemistry, 1988 , vol. 41, # 7 p. 1087 - 1097

 Customs

HS Code 2914400090
Summary 2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Synonyms

Ethanone, 1-(1,8-dihydroxy-3-methyl-2-naphthalenyl)-
Dianellidin
dianellidine
1,8-dihydroxy-2-acetyl-3-methylnaphthalene
1-(1,8-Dihydroxy-3-methyl-2-naphthyl)ethanone
1-(1,8-Dihydroxy-3-methyl-2-naphthalenyl)ethanone
Musizin
2-acetyl-1,8-dihydroxy-3-methylnaphthalene
Nepodin
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